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The placebo response in pain and depression: in search of a common pathway
Joachim F Wernicke1,Melissa J Ossanna1
1
Eli Lilly and Company, Indianapolis, IN 46285, USA. jfwernicke@lilly.com
DOI: 10.2741/S49 Volume 2 Issue 1, pp.106-111
Published: 01 January 2010
(This article belongs to the Special Issue The mood pain interface)
Abstract

The placebo effect has been extensively studied in many disease states, some of the most notable being pain and depression. Utilizing a Medline search, studies were identified that reported on areas of the brain shown to be involved in either placebo analgesia or mood response. This paper presents a distillation of this research, in an effort to identify a common "placebo pathway" between mood and pain. Placebo-related responses to both analgesia and relief from depression were reported to be associated with an increase in activity in the frontal cortex and a decrease in activity in the thalamus.

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Joachim F Wernicke, Melissa J Ossanna. The placebo response in pain and depression: in search of a common pathway. Frontiers in Bioscience-Scholar. 2010. 2(1); 106-111.