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Balneotherapy and coenzyme Q10 in clinical and experimental medicine

Anna Gvozdjakova1,*,Jarmila Kucharska1,Ľubomir Sykora2,Ram B Singh3
1
Comenius University in Bratislava, Medical Faculty, Pharmacobiochemical Laboratory of 3rd Department of Internal Medicine, Bratislava, Slovakia
2
General Health Insurance Company, Inc., Regional Branch of the General Health Insurance Company, Inc., Žilina, Slovakia
3
Halberg Hospital and Research Institute, Moradabad, India
DOI: 10.2741/S411 Volume 6 Issue 1, pp.29-38
Published: 01 January 2014
(This article belongs to the Special Issue New clinical, technological and therapeutic study of coenzyme Q10)
*Corresponding Author(s):  
Anna Gvozdjakova
E-mail:  
anna.gvozdjakova@fmed.uniba.sk
Abstract

Balneotherapy or Spa therapy is used in neurological, cardiovascular, musculoskeletal, dermatological and gynecological diseases, in infertility as well as in metabolic disturbances. Beneficial effects of balneotherapy at the metabolic level is not fully understood. Authors have documented enhancement of antioxidants concentrations (coenzyme Q10- CoQ10-OX and alpha-tocopherol) of women with gynecological diseases by treatment with natural mineral water (Spa Lucky balneotherapy, Slovakia). In an experiment with rats, drinking of Spa Lucky mineral water decreased oxidative stress and enhanced concentrations of antioxidants CoQ9-OX, CoQ10-OX in the myocardium, and alpha-tocopherol in uterus, ovaries and myocardium. Drinking of Spa Lucky water by rats stimulated myocardial mitochondrial respiration and energy production, and diminished skeletal muscle mitochondrial function. Simultaneous ingestion of coenzyme Q10 with drinking spa water returned mitochondrial parameters to the values of the control group. This pilot study helps explain the role of antioxidants, oxidative stress and mitochondrial energy production in beneficial effects of Spa Lucky balneotherapy.


Key words

Natural mineral water, Balneotherapy, Gynecological diseases, Oxidative stress, Antioxidants, coenzyme Q, alpha-tocopherol, Mitochondrial energy production

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Anna Gvozdjakova, Jarmila Kucharska, Ľubomir Sykora, Ram B Singh. Balneotherapy and coenzyme Q10 in clinical and experimental medicine. Frontiers in Bioscience-Scholar. 2014. 6(1); 29-38.