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Among the three striatin family members, SG2NA was first to arise during evolution

Goutam Kumar Tanti1,Nandini Singarapu1,2,Rohini Muthuswami1,Shyamal K. Goswami1,*
1
School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
2
Department of Molecular Carcinogenesis, University of Texas M. D. Anderson Cancer Center, Smithville, Texas 78957, USA
DOI: 10.2741/S409 Volume 6 Issue 1, pp.1-15
Published: 01 January 2014
(This article belongs to the Special Issue Frontiers in endometriosis)
*Corresponding Author(s):  
Shyamal K. Goswami
E-mail:  
skgoswami@mail.jnu.ac.in
Abstract

Striatin, SG2NA, and zinedin constitute a threemember subfamily of WD-40 repeat proteins. They are found only in metazoans and are likely to have scaffolding functions. Apart from WD-40 repeats, they also have a caveolin-binding motif, a coiled-coil structure, and a calmodulin-binding domain. This paper focuses on the analysis of their evolution as a paradigm of understanding the metazoan scaffolds. Each member of the family forms distinct phylogenetic clusters, wherein striatins, SG2NAs, and zinedins have 13, 10, and 9 conserved motifs, respectively. Furthermore, two of those motifs each in striatin and in zinedin and three in SG2NA are exclusive for the respective subfamily. Of those exclusive motifs for SG2NA, two encompass the caveolin-binding and coiledcoiled domains. Collectively, they show the presence of 11 conserved motifs, suggestive of convergence of individual motifs and creation of patterns. A prokaryotic WD-40 repeat motif pCM-I was found only in the corresponding domain of SG2NA but not in other family members. It is thus hypothesized that striatin family members have evolved from bacteria, and SG2NA was the first member to arise.

Key words

Striatin, Phylogenetic analysis, Conserved motif, nervous system, PP2A, Scaffolding protein

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Goutam Kumar Tanti, Nandini Singarapu, Rohini Muthuswami, Shyamal K. Goswami. Among the three striatin family members, SG2NA was first to arise during evolution. Frontiers in Bioscience-Scholar. 2014. 6(1); 1-15.