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Mesenchymal stem cell therapy for injured growth plate

Awang B Shukrimi1,Mohd H Afizah1,Jacqueline F Schmitt1,James HP Hui1,*
1
Department of Orthopaedic Surgery, National University Health System, National University of Singapore, 1E, Kent Ridge Road, 119288, Singapore
DOI: 10.2741/S407 Volume 5 Issue 2, pp.774-785
Published: 01 January 2013
(This article belongs to the Special Issue Bone growth, regulation, injury and repair)
*Corresponding Author(s):  
James HP Hui
E-mail:  
james_hui@nuhs.edu.sg
Abstract

The growth plate has a limited self-healing capacity. Fractures sustained to the growth plate of young children could cause growth disturbances like angular deformity or growth arrest. Established therapies for injured physis only address related complications. Mesenchymal stem cells (MSCs) are multipotent cells which are capable of differentiating into various cells of the musculoskeletal system. Various MSC types have been tested for physeal regeneration, through in vivo lapine, porcine and ovine models, for the duration of 4-16 weeks. The created defect sizes ranged from 7-50% of the growth plate area, to simulate clinically-encountered cases. In vitro models have also been investigated, as a means to screen potential treatments. The effects of MSCs gathered from these models have revealed its function in the prevention of bone bridge formation, with the subsequent development of organized physeal repair tissue. Possible influential factors like the number of implanted MSCs, preconditioned state, growth factors, chondrocyte-MSC interaction and scaffolds are discussed. Possible further studies to optimize physeal repair based on MSC therapy in articular cartilage are also included.

Key words

Mesenchymal stem cells, Growth Plate, Cartilage, Chondrogenesis, Bone Bridge, Zonal Arrangement, Growth Factors, Articular Cartilage, Chondrocytes, Cartilage Repair, Review

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Awang B Shukrimi, Mohd H Afizah, Jacqueline F Schmitt, James HP Hui. Mesenchymal stem cell therapy for injured growth plate. Frontiers in Bioscience-Scholar. 2013. 5(2); 774-785.