Open Access
The role of natural killer cells in pulmonary immunosurveillance
Pamela Rose Hesker1, Alexander Sasha Krupnick1,*
Department of Surgery and The Alvin Siteman Cancer Center, Washington University School of Medicine, 660 S. Euclid Ave., St Louis, MO
DOI: 10.2741/S391 Volume 5 Issue 2, pp.575-587
Published: 01 January 2013
(This article belongs to the Special Issue Recent advances in experimental lung biology)
*Corresponding Author(s):  
Alexander Sasha Krupnick

Natural killer (NK) cells were originally identified as lymphocytes capable of killing cancer cells without prior sensitization (1). Further characterization of these cells in both humans and rodent models has expanded their role towards a broad-based immunosurveillance of diseased and healthy peripheral tissues. Among peripheral organs, the lung contains the largest percentage of NK cells. Accordingly, NK cells are implicated in many immunological responses within the lung, including innate effector functions as well as initiation of the adaptive immune response. In this article, we review the characteristics of NK cells, current models of NK maturation and cell activation, migration of NKs to the lung, and effector functions of NKs in cancer and infection in the airways. Specific emphasis is placed on the functional significance of NKs in cancer immunosurveillance. Therapeutic modulation of NK cells appears to be a challenging but promising approach to limit cancer, inflammation, and infection in the lung.

Key words

Immunosurveillance, Natural killer cell, Lung cancer, Tumor immunology, Review

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Pamela Rose Hesker, Alexander Sasha Krupnick. The role of natural killer cells in pulmonary immunosurveillance. Frontiers in Bioscience-Scholar. 2013. 5(2); 575-587.