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Sumo paralogs: redundancy and divergencies

Simona Citro1,Susanna Chiocca1,*
1
Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, via Adamello 16, 20139 Milan, Italy
DOI: 10.2741/S388 Volume 5 Issue 2, pp.544-553
Published: 01 January 2013
(This article belongs to the Special Issue Ubiquitin-like proteins)
*Corresponding Author(s):  
Susanna Chiocca
E-mail:  
susanna.chiocca@ieo.eu
Abstract

Although sharing a common conjugation pathway, SUMO1, SUMO2/3 and SUMO4 seem to play preferential roles in the cell. Recently, many regulatory mechanisms contributing to SUMO paralogs specific modification have emerged. SUMO enzymes can discriminate between SUMO paralogs at both conjugation and deconjugation levels. Moreover, many substrates possess characteristics that promote their preference for different SUMO family members. A better knowledge of the mechanisms promoting SUMO specific modification will improve our understanding of the functions of SUMO paralogs in distinct cellular pathways.

Key words

SUMO1, SUMO2/3, SUMO4, Paralog specificity, SIMs, E3 ligases, Desumoylases, Review

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Simona Citro, Susanna Chiocca. Sumo paralogs: redundancy and divergencies. Frontiers in Bioscience-Scholar. 2013. 5(2); 544-553.