Navigation
Open Access
Review
Genomic stability disorders: from budding yeast to humans
Nicolas Carlos Hoch1,2,*,Xianning Lai1,2,Jörg Heierhorst1,2
1
St. Vincent’s Institute of Medical Research, Fitzroy, VIC, Australia
2
Department of Medicine (St. Vincent’s Hospital), University of Melbourne, Fitzroy, VIC, Australia
DOI: 10.2741/S379 Volume 5 Issue 2, pp.396-411
Published: 01 January 2013
(This article belongs to the Special Issue The yeast model: its contribution to understanding human disease)
*Corresponding Author(s):  
Nicolas Carlos Hoch
E-mail:  
nhoch@svi.edu.au
Abstract

Fundamental aspects of eukaryotic molecular and cellular biology are extensively studied in the budding yeast Saccharomyces cerevisiae. Genome maintenance pathways are highly conserved and research into a number of human genetic disorders with increased genome instability and cancer predisposition have benefited greatly from studies in budding yeast. Here, we present some of the examples where yeast research into DNA damage responses and telomere maintenance pathways paved the way to understanding these processes, and their involvement in selected human diseases.

Key words

Budding yeast, DNA repair, Telomeres, Genetic Disorders, Human Disease, Review

Share and Cite
Nicolas Carlos Hoch, Xianning Lai, Jörg Heierhorst. Genomic stability disorders: from budding yeast to humans. Frontiers in Bioscience-Scholar. 2013. 5(2); 396-411.