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Review
Cytosolic (pro)renin and the matter of intracellular renin actions
Jorg Peters1,*
1
Institute of Physiology, University of Greifswald, Greifswalder Str. 11C, D-17495 Karlsburg, Germany
DOI: 10.2741/S366 Volume 5 Issue 1, pp.198-205
Published: 01 January 2013
(This article belongs to the Special Issue Handle region peptide and prorenin receptor)
*Corresponding Author(s):  
Jorg Peters
E-mail:  
joerg.peters@uni-greifswald.de
Abstract

Renin is known as a secretory glycoprotein produced, stored and released by the kidney. Renin cleaves angiotensin (ANG) I from angiotensinogen, which is further cleaved to ANG II by ANG-converting enzyme. ANG II acts via specific receptors located at the cell membrane. Recently renin transcripts have been discovered which encode a cytosolic protein that cannot be secreted. These transcripts are derived from the same renin gene but probably use another promoter located within intron A. Whereas the kidney exclusively expresses the transcript encoding secretory renin, other tissues additionally or exclusively express transcripts encoding cytosolic renin. The cytosolic renin protein exerts functions different and even opposite to those of secretory renin. Whereas secretory renin increases necrotic death rates of cardiac cells, the cytosolic renin isoform even protects cells from necrotic death. This review describes the properties of cytosolic renin and its cellular functions and discusses possible mechanisms of actions particularly in the light of the discovery of direct nuclear and mitochondrial effects of ANG's.

Key words

Angiotensin, Renin, Prorenin, Secretory renin, Cytoplasmatic Renin, Intracellular Renin-Angiotensin System, Review

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Jorg Peters. Cytosolic (pro)renin and the matter of intracellular renin actions. Frontiers in Bioscience-Scholar. 2013. 5(1); 198-205.