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The FOX transcription factors regulate vascular pathology, diabetes and Tregs
Xiao-Feng Yang1,Pu Fang1,Shu Meng1,Michael Jan1,Xinyu Xiong1,Ying Yin1,Hong Wang1
1
Department of Pharmacology and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA. xfyang@temple.edu
DOI: 10.2741/S35 Volume 1 Issue 2, pp.420-436
Published: 01 June 2009
(This article belongs to the Special Issue Amylin in vasodilation, energy expenditure and inflammation)
Abstract

A small number of upstream master genes in "higher hierarchy" controls the expression of a large number of downstream genes and integrates the signaling pathways underlying the pathogenesis of cardiovascular diseases with or without autoimmune inflammatory mechanisms. In this brief review, we organize our analysis of recent progress in characterization of forkhead (FOX) transcription factor family members in vascular pathology, diabetes and regulatory T cells into the following sections: (1) Overview of the FOX transcription factor superfamily; (2) Vascular pathology of mice deficient in FOX transcription factors; (3) Roles of FOX transcription factors in endothelial cell pathology; (4) Roles of FOX transcription factors in vascular smooth muscle cells; (5) Roles of FOX transcription factors in the pathogenesis of diabetes; and (6) Immune system phenotypes of mice deficient in FOX transcription factors. Advances in these areas suggest that the FOX transcription factor family plays important roles in vascular development and in the pathogenesis of autoimmune inflammatory cardiovascular diseases.

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Xiao-Feng Yang, Pu Fang, Shu Meng, Michael Jan, Xinyu Xiong, Ying Yin, Hong Wang. The FOX transcription factors regulate vascular pathology, diabetes and Tregs. Frontiers in Bioscience-Scholar. 2009. 1(2); 420-436.