Navigation
Open Access
Article
The use of hormonal therapy in pediatric heart disease
Brandon M Nathan1,Joseph Sockalosky1,Lara Nelson1,Sarah Lai1,Consolato Sergi1,Anna Petryk1
1
University of Minnesota Amplatz Children's Hospital, 516 Delaware St. S.E., Minneapolis, MN 55455, USA
DOI: 10.2741/S31 Volume 1 Issue 1, pp.358-375
Published: 01 June 2009
(This article belongs to the Special Issue Progresses in heart failure diagnosis and treatment)
Abstract

The endocrine system plays an intricate role in the regulation and modulation of cardiovascular function. Several hormones including thyroid, mineralocorticoid, glucocorticoid, arginine-vasopressin (AVP), and growth hormone (GH) have been investigated as adjunctive therapies in pediatric cardiac disease. Thyroid hormone supplementation appears to be safe in neonatal and pediatric post-operative cardiac patients, but the benefits have been modest and inconsistent. Glucocorticoids appear to decrease the inflammatory response associated with cardiopulmonary bypass in children, but have little effect on clinical outcomes. The role of AVP in pediatric shock remains limited due to inconsistent trial results and its potential side effect profile. Although mineralcorticoids are commonly used to treat neurocardiogenic syncope, little to no benefit has been demonstrated in controlled trials. GH normalizes altered cardiac function in children who are GH deficient, but its effectiveness in the treatment of heart failure has been variable. Overall, the use of these hormones in a variety of pediatric cardiac conditions generally appears to be safe, but their efficacy for relieving symptoms, improving cardiac function, and improving clinical outcomes remains unclear.

Share and Cite
Brandon M Nathan, Joseph Sockalosky, Lara Nelson, Sarah Lai, Consolato Sergi, Anna Petryk. The use of hormonal therapy in pediatric heart disease. Frontiers in Bioscience-Scholar. 2009. 1(1); 358-375.