Open Access
Current advances in identification of cancer biomarkers in saliva
Martha Arellano1,Jiang Jiang1,Xiaofeng Zhou1,Lifeng Zhang1,Hui Ye1,David T Wong1,Shen Hu1
School of Dentistry and Dental Research Institute, University of California at Los Angeles, Los Angeles CA 90095, USA
DOI: 10.2741/S27 Volume 1 Issue 1, pp.296-303
Published: 01 June 2009

Saliva samples from certain disease patients harbor a wide spectrum of proteins, mRNAs, DNAs and other molecules that may be associated with the disease phenotype. If successfully discovered and validated, these informative molecules may serve as biomarkers, leading to the use of non-invasive biofluid for detecting and monitoring the diseases. This article summarizes the current advances in searching for potential biomarkers in saliva for human cancers, especially head and neck/oral cancers. With the new molecular profiling technologies such as microarray and proteomics, we are expecting to reveal highly discriminatory genomic and proteomic targets that can best detect the disease status.

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Martha Arellano, Jiang Jiang, Xiaofeng Zhou, Lifeng Zhang, Hui Ye, David T Wong, Shen Hu. Current advances in identification of cancer biomarkers in saliva. Frontiers in Bioscience-Scholar. 2009. 1(1); 296-303.