Open Access
The physiopathology of lipoprotein (a)
Fabio Galvano1,Michele Malaguarnera1,Marco Vacante1,Massimo Motta1,Cristina Russo1,Giulia Malaguarnera1,Nicolantonio D'Orazio1,Lucia Malaguarnera1
Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Italy
DOI: 10.2741/S107 Volume 2 Issue 3, pp.866-875
Published: 01 June 2010
(This article belongs to the Special Issue Biochemical markers in biological fluids)

Lipoprotein(a) (also called Lp(a)) is a lipoprotein subclass. Different studies have identified Lp(a) as a putative risk factor for atherosclerotic diseases such as coronary artery disease and stroke. The physiological role of Lp(a) in humans is still unclear, but it seems that individuals with low concentrations of plasma Lp(a) manifest no deficiency syndrome or disease. Because of the high homology between plasminogen and apo(a) it is conceivable that Lp(a) plays a role in the coagulation system, especially in to thrombosis and impaired fibrinolysis processes. It can also contribute to coronary disease and can accumulate in the arterial walls and cerebral vessels. Lp(a) seems to play an active role in acute inflammation promoting the enhancement of intercellular adhesion molecules; that way it can contribute to develop atherosclerosis. Finally, we underline the relationship among Lp(a) levels and others inflammations molecules such as fibrinogen, fibronectin and TGF- beta.

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Fabio Galvano, Michele Malaguarnera, Marco Vacante, Massimo Motta, Cristina Russo, Giulia Malaguarnera, Nicolantonio D'Orazio, Lucia Malaguarnera. The physiopathology of lipoprotein (a). Frontiers in Bioscience-Scholar. 2010. 2(3); 866-875.