Open Access
Natural killer T cell-mediated immunotherapy for malignant diseases
Shinichiro Motohashi1,Toshinori Nakayama1
Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670 Japan
DOI: 10.2741/S10 Volume 1 Issue 1, pp.108-116
Published: 01 June 2009
(This article belongs to the Special Issue Immunotherapy based on innate lymphocytes)

Human invariant Valpha24 Natural Killer T (NKT) cells are unique lymphocyte subsets, characterized by an invariant T-cell receptor Valpha24 chain paired with Vbeta11. Recent findings have highlighted the role of NKT cells in tumor immunity. Valpha24 NKT cells are activated by a specific glycolipid ligand, alpha-Galactosylceramide and rapidly produce high levels of cytokines upon stimulation, thereby modulating other immune cells such as NK cells antigen-specific CD4+ and CD8+ T cells and dendritic cells. Abnormalities in the numbers and functions of Valpha24 NKT cells have been observed in patients with various malignant diseases. Therefore, therapeutic strategies have recently focused on the reconstitution of an adequate number of functionally sufficient Valpha24 NKT cells which is thought to be logical and reasonable for cancer treatment. The quantitative alteration and functional impairment of circulating Valpha24 NKT cells are herein reviewed in various cancer-bearing patients and the progress to date in the clinical applications of NKT cell-based tumor immunotherapy is summarized.

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Shinichiro Motohashi, Toshinori Nakayama. Natural killer T cell-mediated immunotherapy for malignant diseases. Frontiers in Bioscience-Scholar. 2009. 1(1); 108-116.