Open Access
Low protein diets are mainstay for management of chronic kidney disease
Natale Gaspare De Santo1,Alessandra Perna1,Massimo Cirillo1
Second University of Naples, Nephrology, Naples, Italy.
DOI: 10.2741/234 Volume 3 Issue 4, pp.1432-1442
Published: 01 June 2011
(This article belongs to the Special Issue Dietary approaches to prevent chronic-degenerative diseases)

Low protein diets, made either of natural foods or of L-essential amino acids and/or their nitrogen-free ketoanalogues, are feasible, safe, and efficient means to reduce disease progression in patients with chronic kidney disease and do not prejudice patient outcomes once they get into Renal Replacement Therapy. They ameliorate symptomatology, grant a positive nitrogen balance, reduce proteinuria, improve osteodystrophy and lipid profile, reduce serum concentrations of uric acid, phosphate, and maintain plasma bicarbonate within normal limits thus preventing metabolic acidosis. They also reduce the number of hypotensive drugs and the quantity of erythropoietin to be administered to achieve target hemoglobin concentrations, and do not deteriorate quality of life. On the contrary, they retard progression of chronic kidney disease. There is a need to motivate patients to increase adherence to.

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Natale Gaspare De Santo, Alessandra Perna, Massimo Cirillo. Low protein diets are mainstay for management of chronic kidney disease. Frontiers in Bioscience-Scholar. 2011. 3(4); 1432-1442.