Special Issue

The dynamic roles of glial and stromal cells in neurological diseases

Submission Deadline: 01 December 2021
Articles: 1
Special Issue Editor
Guest Editor
Prof. Georgios Giamas
University of Sussex
Expertise: Kinases; Extracellular Vesicles; Tumor Microenvironment; Cancer
Thomas Simon, PhD
University of Southern California
Expertise: Central Nervous System; Cancer; Microenvironment; Extracellular Vesicles
Special Issue Information

Dear Colleagues,

Multiple cell types surround neurons in the central nervous system (CNS), including glial cells like astrocytes, oligodendrocytes and microglial cells, which play key roles to maintain homeostasis and support the neuronal machinery. Other non-neuronal cells, such as endothelial cells and pericytes, are also directly implicated in the CNS structure and functions.

Consequently, glial cells are also now well-known for their involvement in diseases that set in the CNS, including neurological disorders such as Parkinson’s Disease. In this context, glial cells interact with each other to organize an integrated reaction to fight disease progression and protect neuronal integrity; nevertheless, maintenance of this reactive state in the glial cells, such as during chronic inflammation, can eventually be detrimental to neurons. In the same way, the implication of glial cells and other non-neuronal / stromal cells in brain tumor development has been recently acknowledged, with an increasing number of reports showing how tumor cells in the brain can hijack their direct microenvironment, causing cells such as astrocytes to eventually become a strong support for cancer growth as the disease progresses.

A better knowledge of both the cellular and molecular mechanisms underlying the roles of glial cells and other non-neuronal cells in neurological diseases can provide with highly valuable inputs for developing new therapeutic strategies and diagnostic tools, with the aim to improve patients’ quality of life. Accordingly, recent technological advancements, such as single cell sequencing, and improved understanding of intercellular communication means, including extracellular vesicles, have allowed for a more complete description of the CNS cellular compartment organization.

The present collection will thus introduce the latest developments in our understanding of the roles of glial cells and other non-neuronal / stromal cells of the CNS in neurological diseases, with an extra focus put on those showing high potential for future clinical applications.

Prof. Georgios Giamas and Dr. Thomas Simon

Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at https://jour.ipublishment.com/bri by registering and logging into this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Central Nervous System; Glial Cells; Stromal Cells; Neurological Disease; Microenvironent
Planned Paper(s)

Title: Fractal Analysis in the Quantification of Medical Imaging Associated with Multiple Sclerosis Pathology

Author(s): Maria-Alexandra Paun, Mihai-Virgil Nichita, Vladimir-Alexandru Paun and Viorel-Puiu Paun

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Published Papers (1 papers)
Open Access

The role of astrocytes in brain metastasis at the interface of circulating tumour cells and the blood brain barrier

Layla Burn, Nicholas Gutowski, Jacqueline Whatmore, Georgios Giamas, Md Zahidul Islam Pranjol
Frontiers in Bioscience-Landmark Volume 26 Issue 9, pp.590-601
Managing Editor: Michele Papa
DOI: 10.52586/4969 Published: 30 September 2021