Cancer Metabolism and the Tumor Microenvironment
Nearly a century ago, the discovery of the Warburg effect unveiled the link between oncogenesis and metabolism. Altered metabolism is found across a variety of cancer cell types. While normal cells typically depend on mitochondrial oxidation to meet their bioenergetic needs, cancer cells mostly utilize aerobic glycolysis for energy production and proliferative aggression. The discovery and subsequent vigorous investigation of oncogenes and tumor suppressors have brought enormous progress to the understanding of cancer pathogenesis. Mutations or expression changes in oncogenes and tumor suppressors are widely reported to alter metabolic pathways to fuel cancer pathogenicity. Many of the signaling pathways that drive tumorigenesis directly regulate cellular metabolism. In addition to oncogene-driven metabolic reprogramming, the oncometabolites themselves modulate cell signaling and differentiation and promote metastasis of cancer cells. Metabolic preprogramming is widely considered as a hallmark of cancer.
Nevertheless, tumor heterogeneity and complexity present tremendous challenges to the profound understanding of cancer metabolism. Solid tumors are disorganized, being populated with many cell types including stromal fibroblasts, endothelial cells from blood vessels, immune cells, and malignant cancer cells. Accumulating evidence has illustrated the importance of comprehending bilateral interactions between a primary tumor and its microenvironment. Metabolic alterations and interactions represent an attractive therapeutic target for cancer and encouraging results with drugs targeting metabolic processes have been obtained. A recent landmark achievement of cancer research is the clinical application of immunotherapy. The tumor microenvironment tends to be immunosuppressive, enabling cancer immune evasion. It has been increasingly recognized that cancer metabolism modulates local immune response. The cancer cell metabolites may suppress tumor immunity by regulating T cell function directly or through crippling antigen presenting cells, primarily dendritic cells. An in-depth understanding of cancer metabolic landscape will be necessary to find more effective cancer therapies.
This Special Issue is centered around all the various aspects of metabolic crosstalk in cancer and aims to compile a collection of original and review articles on this topic. We particularly welcome the submissions that address the modulation of immune microenvironment by cancer metabolism.
Dr. Chuanjin Wu
Manuscripts should be submitted online at https://jour.ipublishment.com/bri by registering and logging into this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.
Please visit the Instructions for Authors page before submitting a manuscript. Submitted papers should be well formatted and written in clear, concise English and should contain all essential data in order to make the presentation clear and the results of the study replicable. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see