Special Issue

Oxidative Stress in Neurodegenerative Disorders

Submission Deadline: 10 December 2021
Articles: 2
Special Issue Editor
Guest Editor
Dr. Ghulam Md Ashraf
Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia
Expertise: Neurology
Special Issue Information

Dear Colleagues,

Oxidative stress occurs due to the imbalance between antioxidants and free radicals in the body, which can further result in tissue and cell injury. In the aging process, oxidative stress has a noteworthy contribution. The mitochondrial respiratory chain and enzymatic activities are the endogenous sources of reactive oxygen species. Various oxidizing chemicals, ionizing radiation, and ultraviolet light are known as the inducing stressors of exogenous reactive oxygen species. Reactive oxygen species play a role as a vital second messenger in cell signaling pathways at lower concentrations. Nonetheless, long-term exposure and at high concentrations, reactive oxygen species can result in injury of various cellular macromolecules, including lipids, proteins, and DNA, which can further lead to apoptotic and necrotic cell death.

A lower level of antioxidant activity has been detected in the brain as compared to other tissues. Indeed, cells have the capacity to counteract oxidant injury via controlling their homeostatic balance under normal conditions. Nevertheless, the ability of cells to preserve the redox balance reduces during the advancement of age-associated neurodegenerative disorders, which can further result in neuronal injury, mitochondrial dysfunction, and buildup of free radicals. Oxidative stress level elevates during the aging process. Moreover, oxidative stress is responsible for the advancement of multiple neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, etc. Findings from genetic research have suggested that various proteins including superoxide dismutase, amyloid-β, and α-synuclein play a substantial role in pathogenesis of amyotrophic lateral sclerosis, Alzheimer's, and Parkinson's diseases, respectively. Furthermore, these proteins are the key constituents of the neuronal deposits linked with these neurodegenerative disorders. These proteins have also been reported to interact with redox-active metal ions that further mediate free radicals generation. Aberrant interactions amid proteins can lead to abnormal extracellular and intracellular deposition of self-aggregating misfolded proteins with the generation of higher-order insoluble fibrils are the commonly observed pathological hallmarks of several neurodegenerative diseases.

In this special thematic issue, we welcome neuroscientists to contribute their articles exploring the linkage of oxidative stress and neurodegenerative disorders. Furthermore, this issue aimed to collect articles highlighting the recent growth in the management of neurodegenerative insults.

Dr. Ghulam Md Ashraf

Guest Editor

Manuscript Submission Information

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Neurodegeneration; Alzheimer's Disease; Oxidative Stress; Free Radicals; Brain; Central Nervous System; Cerebrospinal Fluid; Dementia; Mitochondrial DNA; Calcium Ions Homeostasis; Drug Targeting; Huntington’s Diseases, Amyotrophic Lateral Sclerosis; Metals; Mild Cognitive Impairment; Neurodegenerative Disorders, Parkinson’s Disease; Therapeutic Agents
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Published Papers (2 papers)
Open Access

Nanomaterials in Alzheimer’s disease treatment: a comprehensive review

Maryam Faiyaz, Mohd. Azhardin Ganayee, Salman Akhtar, Saravanan Krishnan, Bableen Flora, Deeksha Dogra, Niraj Kumar Jha, Dinesh Kumar Chellappan, Poonam Negi, Kamal Dua, Kavindra Kumar Kesari, Piyush Kumar Gupta
Frontiers in Bioscience-Landmark Volume 26 Issue 10, pp.851-865
Managing Editor: Ghulam Md Ashraf
DOI: 10.52586/4992 Published: 30 October 2021
Open Access

Anti-Parkinson’s evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals

Uzma Saleem, Shabana Bibi, Muhammad Ajmal Shah, Bashir Ahmad, Ammara Saleem, Zunera Chauhdary, Fareeha Anwar, Nimra Javaid, Sundas Hira, Muhammad Furqan Akhtar, Ghulam Mujtaba Shah, Muhammad Saad Khan, Haji Muhammad, Muhammad Qasim, Mohammad Alqarni, Majed A. Algarni, Renald Blundell, Celia Vargas-De-La-Cruz, Oscar Herrera-Calderon, Reem Hasaballah Alhasani
Frontiers in Bioscience-Landmark Volume 26 Issue 11, pp.1031-1051
DOI: 10.52586/5007 Published: 30 November 2021