Special Issue
Genetically-modified animals as research models in development and disease
Submission Deadline: 31 December 2012
Articles: 37
Special Issue Editor
Guest Editor
Vicente Andres
Ph.D., Dept. of Molecular and Cellular Pathology and Therapy, Jaime Roig 11, 46010 Valencia (Spain)
Expertise: 60 publications, 16 grants, Editor of Frontiers in Bioscience, Cardiologia Practica
Manuscript Submission Information

Manuscripts should be submitted online at https://jour.ipublishment.com/bri by registering and logging into this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

Please visit the Instructions for Authors page before submitting a manuscript. Submitted papers should be well formatted and written in clear, concise English and should contain all essential data in order to make the presentation clear and the results of the study replicable. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see

here.

Keywords
Genes and Genetics, Molecular Biology
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Published Papers (37 papers)
Open Access
Article
Cell fusion: biological perspectives and potential for regenerative medicine
Manuel Alvarez-Dolado
Frontiers in Bioscience-Landmark Volume 12 Issue 1, pp.1-12
Managing Editor: Vicente Andres
DOI: 10.2741/2044 Published: 01 January 2007
Open Access
Article
Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins
Sonsoles Hortelano, Miriam Zeini, Marta Casado, Paloma Martín-Sanz, Lisardo Boscá
Frontiers in Bioscience-Landmark Volume 12 Issue 1, pp.13-21
Managing Editor: Vicente Andres
DOI: 10.2741/2045 Published: 01 January 2007
Open Access
Article
Genetically engineered mice as a model for studying cardiac arrhythmias
Juan Tamargo, Ricardo Caballero, Lucía Núñez, Ricardo Gómez, Miguel Vaquero, Eva Delpón
Frontiers in Bioscience-Landmark Volume 12 Issue 1, pp.22-38
Managing Editor: Vicente Andres
DOI: 10.2741/2046 Published: 01 January 2007
Open Access
Article
Age-related cardiac deterioration: insights from Drosophila
Robert J Wessells, Rolf Bodmer
Frontiers in Bioscience-Landmark Volume 12 Issue 1, pp.39-48
Managing Editor: Vicente Andres
DOI: 10.2741/2047 Published: 01 January 2007
Open Access
Article
The risk for cardiovascular disease in women: from estrogens to selective estrogen receptor modulators
Antonio Cano, Carlos Hermenegildo, Pilar Oviedo, Juan Jose Tarín
Frontiers in Bioscience-Landmark Volume 12 Issue 1, pp.49-68
Managing Editor: Vicente Andres
DOI: 10.2741/2048 Published: 01 January 2007
Open Access
Article
Controlled gene activation and inactivation in the mouse
Moisés Mallo
Frontiers in Bioscience-Landmark Volume 11 Issue 1, pp.313-327
Managing Editor: Vicente Andres
DOI: 10.2741/1799 Published: 01 January 2006
Open Access
Article
Endometriosis: harmful survival of an ectopic tissue
Janos Garai, Valeria Molnar, Tamas Varga, Miklos Koppan, Attila Torok, Jozsef Bodis
Frontiers in Bioscience-Landmark Volume 11 Issue 1, pp.595-619
Managing Editor: Vicente Andres
DOI: 10.2741/1821 Published: 01 January 2006
Open Access
Article
New animal models to study the role of tyrosinase in normal retinal development
Alfonso Lavado, Lluis Montoliu
Frontiers in Bioscience-Landmark Volume 11 Issue 1, pp.743-752
Managing Editor: Vicente Andres
DOI: 10.2741/1832 Published: 01 January 2006
Open Access
Article
The GCK II and III subfamilies of the STE20 group kinases
Celia María Pombo, Thomas Force, John Kyriakis, Emilio Nogueira, Miguel Fidalgo, Juan Zalvide
Frontiers in Bioscience-Landmark Volume 12 Issue 3, pp.850-859
Managing Editor: Vicente Andres
DOI: 10.2741/2107 Published: 01 January 2007
Open Access
Article
Understanding the role of dietary components on atherosclerosis using genetic engineered mouse models
Alfonso J Sarria, Joaquin C Surra, Sergio Acin, Ricardo Carnicer, Maria A Navarro, Jose M Arbones-Mainar, Natalia Guillen, Maria V Martinez-Gracia, Carmen Arnal, Jesus Osada
Frontiers in Bioscience-Landmark Volume 11 Issue 1, pp.955-967
Managing Editor: Vicente Andres
DOI: 10.2741/1852 Published: 01 January 2006
Open Access
Article
Mammalian genome targeting using site-specific recombinases
Angel Luis García-Otín, Florian Guillou
Frontiers in Bioscience-Landmark Volume 11 Issue 1, pp.1108-1136
Managing Editor: Vicente Andres
DOI: 10.2741/1867 Published: 01 January 2006
Open Access
Article
Cyclins and CDKS in development and cancer: lessons from genetically modified mice
David Santamaria, Sagrario Ortega
Frontiers in Bioscience-Landmark Volume 11 Issue 1, pp.1164-1188
Managing Editor: Vicente Andres
DOI: 10.2741/1871 Published: 01 January 2006
Open Access
Article
Antiatherogenic role of high-density lipoproteins: insights from genetically engineered-mice
Joan Carles Escola-Gil, Laura Calpe-Berdiel, Xavier Palomer, Vicent Ribas, Jordi Ordonez-Llanos, Francisco Blanco-Vaca
Frontiers in Bioscience-Landmark Volume 11 Issue 2, pp.1328-1348
Managing Editor: Vicente Andres
DOI: 10.2741/1887 Published: 01 May 2006
Open Access
Article
Transcriptional profiling of early onset diet-induced atherosclerosis in apolipoprotein E-deficient mice
Claudia Castro, Josep María Campistol, Domingo Barettino, Vicente Andrés
Frontiers in Bioscience-Landmark Volume 10 Issue 2, pp.1932-1945
Managing Editor: Vicente Andres
DOI: 10.2741/1669 Published: 01 May 2005
Open Access
Article
Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemia
Costanza Emanueli, Andrea Caporali, Nicolle Krankel, Brunella Cristofaro, Sophie Van Linthout, Paolo Madeddu
Frontiers in Bioscience-Landmark Volume 12 Issue 6, pp.2003-2012
Managing Editor: Vicente Andres
DOI: 10.2741/2205 Published: 01 January 2007
Open Access
Article
Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice
Herminia Gonzalez-Navarro, Marian Vila-Caballer, Maria F Pastor, Angela Vinue, Morris F White, Deborah Burks, Vicente Andres
Frontiers in Bioscience-Landmark Volume 12 Issue 6, pp.2291-2298
Managing Editor: Vicente Andres
DOI: 10.2741/2231 Published: 01 January 2007
Open Access
Article
Yeast as a model system to study glucose-mediated signalling and response
Pascual Sanz
Frontiers in Bioscience-Landmark Volume 12 Issue 6, pp.2358-2371
Managing Editor: Vicente Andres
DOI: 10.2741/2238 Published: 01 January 2007
Open Access
Article
Vitamin D and cancer: an update of in vitro and in vivo data
Paloma Ordonez-Moran, Maria Jesus Larriba, Natalia Pendas-Franco, Oscar Aguilera, Jose Manuel Gonzalez-Sancho, Alberto Munoz
Frontiers in Bioscience-Landmark Volume 10 Issue 3, pp.2723-2749
Managing Editor: Vicente Andres
DOI: 10.2741/1731 Published: 01 September 2005
Open Access
Article
Atheroma development in apolipoprotein E-null mice is not affected by partial inactivation of PTEN
Vicente Andrés, Marisol Gascón-Irún, Pier Paolo Pandolfi, Herminia González-Navarro
Frontiers in Bioscience-Landmark Volume 11 Issue 3, pp.2739-2745
Managing Editor: Vicente Andres
DOI: 10.2741/2003 Published: 01 September 2006
Open Access
Article
HIV-1 transgenic expression in mice induces selective atrophy of fast-glycolytic skeletal muscle fibers
Antonio L Serrano, Merce Jardi, Monica Suelves, Paul E Klotman, Pura Munoz-Canoves
Frontiers in Bioscience-Landmark Volume 13 Issue 8, pp.2797-2805
Managing Editor: Vicente Andres
DOI: 10.2741/2886 Published: 01 January 2008
Open Access
Article
Cyclooxygenase 2: understanding the pathophysiological role through genetically altered mouse models
Paloma Martín Sanz, Sonsoles Hortelano, Lisardo Bosca, Marta Casado
Frontiers in Bioscience-Landmark Volume 11 Issue 3, pp.2876-2888
Managing Editor: Vicente Andres
DOI: 10.2741/2016 Published: 01 September 2006
Open Access
Article
The plasminogen activation system in skeletal muscle regeneration: antagonistic roles of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1)
Monica Suelves, Berta Vidal, Vanessa Ruiz, Bernat Baeza-Raja, Angels Diaz-Ramos, Isabel Cuartas, Frederic Lluis, Maribel Parra, Merce Jardi, Roser Lopez-Alemany, Antonio L Serrano, Pura Munoz-Canoves
Frontiers in Bioscience-Landmark Volume 10 Issue 3, pp.2978-2985
Managing Editor: Vicente Andres
DOI: 10.2741/1754 Published: 01 September 2005
Open Access
Article
An insight into the pathophysiology of thrombosis in antiphospholipid syndrome
Ivan G Palomo, Fabian M Segovia, Marcelo L Alarcon, Barbara Y Fuentes, Jaime G Pereira, Armando Rojas, Ricardo Forastiero
Frontiers in Bioscience-Landmark Volume 12 Issue 8, pp.3093-3103
Managing Editor: Vicente Andres
DOI: 10.2741/2297 Published: 01 May 2007
Open Access
Article
Stem cells for cardiac repair: state of the art
Gianluigi Condorelli, Cesare Peschle
Frontiers in Bioscience-Landmark Volume 10 Issue 3, pp.3143-3150
Managing Editor: Vicente Andres
DOI: 10.2741/1771 Published: 01 September 2005
Open Access
Article
Mouse models to study angiogenesis in the context of cardiovascular diseases
Thierry Couffinhal, Pascale Dufourcq, Laurent Barandon, Lionel Leroux, Cecile Duplaa
Frontiers in Bioscience-Landmark Volume 14 Issue 9, pp.3310-3325
Managing Editor: Vicente Andres
DOI: 10.2741/3454 Published: 01 January 2009
Open Access
Article
Retromer and sorting nexins in development
Marcel Verges
Frontiers in Bioscience-Landmark Volume 12 Issue 10, pp.3825-3851
Managing Editor: Vicente Andres
DOI: 10.2741/2355 Published: 01 May 2007
Open Access
Article
Genetically-engineered animals as research models for atherosclerosis: their use for the characterization of PPAR agonists in the treatment of cardiometabolic disorders
Catherine Fievet, Jean-Charles Fruchart, Bart Staels
Frontiers in Bioscience-Landmark Volume 12 Issue 11, pp.4132-4156
Managing Editor: Vicente Andres
DOI: 10.2741/2376 Published: 01 May 2007
Open Access
Article
Potential contribution of bone marrow-derived precursors to vascular repair and lesion formation: lessons from animal models of vascular diseases
Hiroshi Iwata, Masataka Sata
Frontiers in Bioscience-Landmark Volume 12 Issue 11, pp.4157-4167
Managing Editor: Vicente Andres
DOI: 10.2741/2377 Published: 01 May 2007
Open Access
Article
Murine models to investigate the influence of diabetic metabolism on the development of atherosclerosis and restenosis
Herminia Gonzalez-Navarro, Deborah J Burks, Vicente Andres
Frontiers in Bioscience-Landmark Volume 12 Issue 7, pp.4439-4455
Managing Editor: Vicente Andres
DOI: 10.2741/2400 Published: 01 May 2007
Open Access
Article
Protein isoprenylation in biology and disease: general overview and perspectives from studies with genetically engineered animals
Dolores Perez-Sala
Frontiers in Bioscience-Landmark Volume 12 Issue 7, pp.4456-4472
Managing Editor: Vicente Andres
DOI: 10.2741/2401 Published: 01 May 2007
Open Access
Article
Of mice without pockets: mouse models to study the function of Rb family proteins
Anxo Vidal, Carmen Carneiro, Juan B Zalvide
Frontiers in Bioscience-Landmark Volume 12 Issue 7, pp.4483-4496
Managing Editor: Vicente Andres
DOI: 10.2741/2403 Published: 01 May 2007
Open Access
Article
Function and regulation of the complement system in cardiovascular diseases
Riina Oksjoki, Petri T Kovanen, Seppo Meri, Markku O Pentikainen
Frontiers in Bioscience-Landmark Volume 12 Issue 12, pp.4696-4708
Managing Editor: Vicente Andres
DOI: 10.2741/2419 Published: 01 May 2007
Open Access
Article
Role of Bcl-2 family members on apoptosis: what we have learned from knock-out mice
Ramon Roset, Laura Ortet, Gabriel Gil-Gomez
Frontiers in Bioscience-Landmark Volume 12 Issue 12, pp.4722-4730
Managing Editor: Vicente Andres
DOI: 10.2741/2421 Published: 01 May 2007
Open Access
Article
Knock-out mouse models of proprotein convertases: unique functions or redundancy?
John W M Creemers, Abdel-Majid Khatib
Frontiers in Bioscience-Landmark Volume 13 Issue 13, pp.4960-4971
Managing Editor: Vicente Andres
DOI: 10.2741/3055 Published: 01 May 2008
Open Access
Article
Regulation of cell proliferation and differentiation in the kidney
Neal I Alcalay, Gregory B Vanden Heuvel
Frontiers in Bioscience-Landmark Volume 14 Issue 13, pp.4978-4991
Managing Editor: Vicente Andres
DOI: 10.2741/3582 Published: 01 June 2009
Open Access
Article
Control of atherosclerotic plaque vulnerability: insights from transgenic mice
Sylvia Heeneman, Esther Lutgens, Kitty B Schapira, Mat J A P Daemen, Erik A L Biessen
Frontiers in Bioscience-Landmark Volume 13 Issue 16, pp.6289-6313
Managing Editor: Vicente Andres
DOI: 10.2741/3155 Published: 01 May 2008
Open Access
Article
The use of genetically engineered model systems for research on human aging
Guenter Lepperdinger, Peter Berger, Michael Breitenbach, Kai-Uwe Frohlich, Johannes Grillari, Beatrix Grubeck-Loebenstein, Frank Madeo, Nadege Minois, Werner Zwerschke, Pidder Jansen-Durr
Frontiers in Bioscience-Landmark Volume 13 Issue 18, pp.7022-7031
Managing Editor: Vicente Andres
DOI: 10.2741/3207 Published: 01 May 2008