Special Issue

Cellular response to mitochondrial dysfunction and pathogenic mtDNA mutations

Submission Deadline: 31 January 2022
Articles: 6
Special Issue Editor
Guest Editor
Prof. Dr. Yau-Huei Wei
Center for Mitochondrial Medicine and Free Radical Research, Changhua Christian Hospital, Changhua City, Taiwan 50046
Expertise: Mitochondrial Disease; Mitochondrial DNA Mutation; Stem Cells; iPSC; Metabolic Reprogramming
Special Issue Information

Dear Colleagues,

Mitochondrial DNA (mtDNA) mutations result in not only inefficient supply of ATP but also increased production of reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide in mitochondria of the affected tissues of patients with mitochondrial disease or in elderly subjects. Extensive studies have demonstrated that such an increase of oxidative stress contributes to alterations in the gene expression and activities of enzymes in several metabolic pathways. Several antioxidant enzymes are altered and oxidative damage to DNA, RNA, proteins, and lipids are increased in tissues and cultured cells from mitochondrial disease patients or elderly subjects. The changes at the protein and activity levels of several metabolic pathways result in metabolic reprogramming, which plays an important role in adaptive response and survival of human cells harboring a pathogenic mtDNA mutation. This special issue is focused on the molecular mechanism and consequences of human cell response to pathogenic mtDNA mutation and/or mitochondrial dysfunction.

Prof. Dr. Yau-Huei Wei

Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at https://jour.ipublishment.com/bri by registering and logging into this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

Please visit the Instructions for Authors page before submitting a manuscript. Submitted papers should be well formatted and written in clear, concise English and should contain all essential data in order to make the presentation clear and the results of the study replicable. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see


Mitochondrial DNA Mutation; Mitochondrial Dysfunction; Mitochondrial Disease; Mitophagy; Oxidative Stress
Planned Paper(s)

Tilte: Oxidative damage elicited by overproduction of reactive oxygen species in cultured cells of patients harboring the mitochondrial DNA mutations associated with mitochondrial encephalomyopathies

Author: Dr. Yi-Shing Ma

Tilte: Roles of mitochondrial DNA alterations and mitochondrial dysfunction in the progression and malignancy of human cancers

Author: Dr. Chen-Sung Lin

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Published Papers (6 papers)
Open Access

Linking telomere loss and mitochondrial dysfunction in chronic disease

Ana Carlota Gonzalez-Ebsen, Niels Gregersen, Rikke K.J. Olsen
Frontiers in Bioscience-Landmark Volume 22 Issue 1, pp.117-127
DOI: 10.2741/4475 Published: 01 January 2017
Open Access

Oxidative DNA and mitochondrial DNA change in patients with SLE

Hui-Ting Lee, Tsai-Hung Wu, Chen-Sung Lin, Chyou-Shen Lee, Siao-Cian Pan, Deh-Ming Chang, Yau-Huei Wei, Chang-Youh Tsai
Frontiers in Bioscience-Landmark Volume 22 Issue 3, pp.493-503
DOI: 10.2741/4497 Published: 01 January 2017
Open Access

Mitochondria in the pathophysiology of Alzheimer’s and Parkinson’s diseases

Isaac G. Onyango, Shaharyar M. Khan, James P. Bennett
Frontiers in Bioscience-Landmark Volume 22 Issue 5, pp.854-872
DOI: 10.2741/4521 Published: 01 January 2017
Open Access

Tissue transglutaminase (TG2) and mitochondrial function and dysfunction

Thung-S. Lai, Cheng-Jui Lin, Yu-Ting Wu, Chih-Jen Wu
Frontiers in Bioscience-Landmark Volume 22 Issue 7, pp.1114-1137
DOI: 10.2741/4536 Published: 01 March 2017
Open Access

Role of mitochondrial DNA variation in the pathogenesis of diabetes mellitus

Soo Heon Kwak, Kyong Soo Park
Frontiers in Bioscience-Landmark Volume 21 Issue 6, pp.1151-1167
DOI: 10.2741/4447 Published: 01 June 2016
Open Access

Role of mitochondrial function in cell death and body metabolism

Myung-Shik Lee
Frontiers in Bioscience-Landmark Volume 21 Issue 6, pp.1233-1244
DOI: 10.2741/4453 Published: 01 June 2016