Special Issue
Leader sequences of coronavirus are altered during infection
Submission Deadline: 31 December 2018
Articles: 56
Special Issue Editor
Guest Editor
Li Liu
Professor, Department of Microbiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
Expertise: 51 publications, 12 grants, Editor of Frontiers in Bioscience, Basic and Clinical Medicine
Manuscript Submission Information

Manuscripts should be submitted online at https://jour.ipublishment.com/bri by registering and logging into this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

Please visit the Instructions for Authors page before submitting a manuscript. Submitted papers should be well formatted and written in clear, concise English and should contain all essential data in order to make the presentation clear and the results of the study replicable. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see

here.

Keywords
Cancer, Cell Biology, Molecular Biology, Signaling
Share This Special Issue
Published Papers (56 papers)
Open Access
Article

Leader sequences of coronavirus are altered during infection

Li Liu, Wei Chen
Frontiers in Bioscience-Landmark Volume 23 Issue 1, pp.27-35
Managing Editor: Li Liu
DOI: 10.2741/4579 Published: 01 January 2018
Open Access
Article

Dysregulated circRNAs and ceRNA network in esophageal squamous cell carcinoma

Chao Jiang, Dafu Xu, Zhenbing You, Keping Xu, Wenze Tian
Frontiers in Bioscience-Landmark Volume 24 Issue 2, pp.277-290
Managing Editor: Li Liu
DOI: 10.2741/4717 Published: 01 January 2019
Open Access
Article

Amelioration of prediabetes-induced changes of dendritic structural plasticity

Feiyan Fan, Jing Qi, Wenshi Wang, Nan Liu, Hui Liu, Xiaoshan Xu, Xin Wang, Yanyang Tu, Wen Wang, Jianfang Fu
Frontiers in Bioscience-Landmark Volume 24 Issue 2, pp.291-302
Managing Editor: Li Liu
DOI: 10.2741/4718 Published: 01 January 2019
Open Access
Article

Nobiletin sensitizes colorectal cancer cells to oxaliplatin by PI3K/Akt/MTOR pathway

Nan Li, Zhenghua Zhang, Guodan Jiang, Honglan Sun, Deming Yu
Frontiers in Bioscience-Landmark Volume 24 Issue 2, pp.303-312
Managing Editor: Li Liu
DOI: 10.2741/4719 Published: 01 January 2019
Open Access
Review

The roles of TAM receptor tyrosine kinases in the mammalian testis and immunoprivileged sites

Tingting Deng, Qiaoyuan Chen, Daishu Han
Frontiers in Bioscience-Landmark Volume 21 Issue 2, pp.316-327
Managing Editor: Li Liu
DOI: 10.2741/4390 Published: 01 January 2016
Open Access
Article

miR-1 inhibits migration of gastric cancer cells

Xiu-qing Lin, Wei Wu, Xin Chen, Ren-pin Chen, Fang Wu, Zhou-feng Chen, Er-jiong Huang, Chao Chen
Frontiers in Bioscience-Landmark Volume 25 Issue 3, pp.452-462
Managing Editor: Li Liu
DOI: 10.2741/4813 Published: 01 January 2020
Open Access
Article

Hyperoside exerts potent anticancer activity in skin cancer

Yinghui Kong, Weiguo Sun, Pengfei Wu
Frontiers in Bioscience-Landmark Volume 25 Issue 3, pp.463-479
Managing Editor: Li Liu
DOI: 10.2741/4814 Published: 01 January 2020
Open Access
Article

Lonicerin prevents inflammation and apoptosis in LPS-induced acute lung injury

Li-Zhi Gu, Hong Sun
Frontiers in Bioscience-Landmark Volume 25 Issue 3, pp.480-497
Managing Editor: Li Liu
DOI: 10.2741/4815 Published: 01 January 2020
Open Access
Article

TGF-beta/TGF-beta RII/CLC-3 axis promotes cognitive disorders in diabetes

Feiyan Fan, Jing Qi, Nan Liu, Zhen Wang, Wenshi Wang, Hui Liu, Xiaoshan Xu, Guangfeng Chen, Xin Wang, Hongwei Yang, Mark Johnson, Yanyang Tu, Tao Liu, Jianfang Fu
Frontiers in Bioscience-Landmark Volume 24 Issue 3, pp.482-493
Managing Editor: Li Liu
DOI: 10.2741/4730 Published: 01 January 2019
Open Access
Article

T-96 attenuates inflammation by inhibiting NF-κB in adjuvant-induced arthritis

Yun Yu, Bian Yong, Changliang Xu, Luyong Zhang
Frontiers in Bioscience-Landmark Volume 25 Issue 3, pp.498-512
Managing Editor: Li Liu
DOI: 10.2741/4816 Published: 01 January 2020
Open Access
Article

NF2/Merlin suppresses proliferation and induces apoptosis in colorectal cancer cells

Xingli Wu, Fajiang Mao, Ning Li, Wei Li, Yinbing Luo, Wenyan Shi, Jianlin Ren
Frontiers in Bioscience-Landmark Volume 25 Issue 3, pp.513-525
Managing Editor: Li Liu
DOI: 10.2741/4817 Published: 01 January 2020
Open Access
Article

Forsythiaside A alleviates renal damage in adriamycin-induced nephropathy

Chan Lu, She Feng Zheng, Jinnv Liu
Frontiers in Bioscience-Landmark Volume 25 Issue 3, pp.526-535
Managing Editor: Li Liu
DOI: 10.2741/4818 Published: 01 January 2020
Open Access
Article

Blocking PERK resuces vascular smooth muscle cells from homocysteine-induced ER stress and apoptosis

Wei Li, Fujun Shang, Xiaoli Li, Shaoping Lu, Xiaolin Niu, Zhimin Zhang, Jing Liu, Xue Li, Lianyou Zhao
Frontiers in Bioscience-Landmark Volume 25 Issue 3, pp.536-548
Managing Editor: Li Liu
DOI: 10.2741/4819 Published: 01 January 2020
Open Access
Article

FAM46C suppresses gastric cancer by inhibition of Wnt/β-catenin

Jun Shi, Qiuwei Zhu, Jianbo Wu, Ping Zhu
Frontiers in Bioscience-Landmark Volume 25 Issue 3, pp.549-563
Managing Editor: Li Liu
DOI: 10.2741/4820 Published: 01 January 2020
Open Access
Article

Nanog promotes stem-like traits of glioblastoma cells

Yuan Ye, Mengsi Zhang, Guangning Yan, Qinghua Ma, Zexuan Yan, Lihong Wang, Kaidi Yang, Deyu Guo
Frontiers in Bioscience-Landmark Volume 26 Issue 3, pp.552-565
Managing Editor: Li Liu
DOI: 10.2741/4907 Published: 01 October 2020
Open Access
Article

Silencing NEAT1 suppresses thyroid carcinoma via miR-126/NEAT1/VEGFA axis

Weiwei Zeng, Yan Lin, Hai Lin, Xuemei Wu
Frontiers in Bioscience-Landmark Volume 25 Issue 3, pp.564-576
Managing Editor: Li Liu
DOI: 10.2741/4821 Published: 01 January 2020
Open Access
Article

Withaferin A attenuates ovalbumin induced airway inflammation

Hongmei Zhao, Zhiwei Gao, Shouxiang Xie, Xiang Han, Qingsong Sun
Frontiers in Bioscience-Landmark Volume 24 Issue 3, pp.576-596
Managing Editor: Li Liu
DOI: 10.2741/4737 Published: 01 January 2019
Open Access
Article

The miR-145 rs353291 C allele increases susceptibility to atherosclerosis

Yu Lv, Yihu Yi, Sujie Jia, Xiangdong Peng, Heng Yang, Ren Guo
Frontiers in Bioscience-Landmark Volume 25 Issue 3, pp.577-592
Managing Editor: Li Liu
DOI: 10.2741/4822 Published: 01 January 2020
Open Access
Article

TMEM45A is involved in renal fibrosis in rats by regulating Jagged1/Notch pathway

Jian-zi Lan, Qi Pan, Qing Tao, Xin Shi, Wei-zhun Wang, Bo-wen Xu, Jie-wei Luo
Frontiers in Bioscience-Landmark Volume 25 Issue 4, pp.593-605
Managing Editor: Li Liu
DOI: 10.2741/4823 Published: 01 January 2020
Open Access
Article

Astragaloside IV inhibits human colorectal cancer cell growth

Peng Sun, Yan Liu, Qun Wang, Baichao Zhang
Frontiers in Bioscience-Landmark Volume 24 Issue 3, pp.597-606
Managing Editor: Li Liu
DOI: 10.2741/4738 Published: 01 January 2019
Open Access
Article

Sarpogrelate attenuates pulmonary arterial hypertension via calcium/calcineurin axis

Junli Han, Hongyan Tian, Ya Liu, Fenling Fan
Frontiers in Bioscience-Landmark Volume 24 Issue 4, pp.607-615
Managing Editor: Li Liu
DOI: 10.2741/4739 Published: 01 January 2019
Open Access
Article

Sophocarpine inhibits the growth of gastric cancer cells via autophagy and apoptosis

Yijie Huang, Xinhua Chen, Guohu Guo, Weihong Guo, Qinhai Ma, Jianming Yuan
Frontiers in Bioscience-Landmark Volume 24 Issue 4, pp.616-627
Managing Editor: Li Liu
DOI: 10.2741/4740 Published: 01 March 2019
Open Access
Article

One-step strategy for chondral defect repair

Ying Zhang, Hongbo Tan, Guangxing Chen, Weinan Zeng, Junli Liu, Liu Yang, Fuyou Wang
Frontiers in Bioscience-Landmark Volume 24 Issue 4, pp.628-647
Managing Editor: Li Liu
DOI: 10.2741/4741 Published: 01 March 2019
Open Access
Article

ITGBL1 promotes gastric cancer cell proliferation and invasion via Akt signal pathway

Feng-yan Yin, Huan-peng Qi, ui Qiao, Xiao-hong Lv, Hai-hua Tan
Frontiers in Bioscience-Landmark Volume 26 Issue 4, pp.682-691
Managing Editor: Li Liu
DOI: 10.2741/4912 Published: 01 October 2020
Open Access
Article

cPKCβII is significant to hypoxic preconditioning in mice cerebrum

Yan Lv, Zhichuan Lin, Dongguo Li, Song Han, Nan Zhang, Hongning Zhang, Junfa Li
Frontiers in Bioscience-Landmark Volume 25 Issue 4, pp.683-698
Managing Editor: Li Liu
DOI: 10.2741/4828 Published: 01 January 2020
Open Access
Article

Prognostic gene profiles in the tumor microenvironment of ovarian serous adenocarcinoma

Ruyue Tian, Guiping Zhao, Anni Zhou, Huihui Li, Bangwei Cao, Shuilong Guo
Frontiers in Bioscience-Landmark Volume 26 Issue 4, pp.692-705
Managing Editor: Li Liu
DOI: 10.2741/4913 Published: 01 October 2020
Open Access
Article

Resveratrol reverts Streptozotocin-induced diabetic nephropathy

Huiping Zhu, Sen Zhong, Haihong Yan, Kangyao Wang, Lingwei Chen, Min Zhou, Yunsheng Li
Frontiers in Bioscience-Landmark Volume 25 Issue 4, pp.699-709
Managing Editor: Li Liu
DOI: 10.2741/4829 Published: 01 January 2020
Open Access
Article

ADAR1 promotes HBV replication through its deaminase domain

Lin Yuan, Qianying Jia, Shenyong Yang, Nur Fazleen Binti Idris, Yimin Li, Yang Wang, Ya Zhao, Jieli Hu, Yuan Hu, Ailong Huang, Zeng Tu
Frontiers in Bioscience-Landmark Volume 25 Issue 4, pp.710-721
Managing Editor: Li Liu
DOI: 10.2741/4830 Published: 01 January 2020
Open Access
Article

Life history tradeoffs in humans: increased life expectancy with sperm count reduction

Rui-An Wang, Ping-Ju Zheng, Yi Liu, Lei Shang
Frontiers in Bioscience-Landmark Volume 24 Issue 4, pp.712-722
Managing Editor: Li Liu
DOI: 10.2741/4745 Published: 01 March 2019
Open Access
Article

Structural, functional and histological features of a novel ischemic heart failure model

Yongchun Cui, Fuliang Luo, Bin Li, Liujun Jia, Peng Peng, Chengliang Luo, Xin Wang, Yue Tang
Frontiers in Bioscience-Landmark Volume 24 Issue 4, pp.723-734
Managing Editor: Li Liu
DOI: 10.2741/4746 Published: 01 March 2019
Open Access
Article

Amentoflavone induces cell cycle arrest, apoptosis, and autophagy in BV-2 cells

Zheng Liu, Feng Wang, Hui Ma, Hechun Xia, Jihui Tian, Tao Sun
Frontiers in Bioscience-Landmark Volume 25 Issue 5, pp.798-816
Managing Editor: Li Liu
DOI: 10.2741/4835 Published: 01 January 2020
Open Access
Article

CircRNA_104916 regulates migration, apoptosis and epithelial-mesenchymal transition in colon cancer cells

Lianyong Min, Huaiming Wang, Yongming Zeng
Frontiers in Bioscience-Landmark Volume 24 Issue 5, pp.819-832
Managing Editor: Li Liu
DOI: 10.2741/4753 Published: 01 March 2019
Open Access
Article

Qingyi Decoction amerliorates acute biliary pancreatitis by targeting Gpbar1/NF-kb pathway

Gui-xin Zhang, Chen Zhan, Kai Wang, Jian Han, Dong Shang, Hai-long Chen
Frontiers in Bioscience-Landmark Volume 24 Issue 5, pp.833-848
Managing Editor: Li Liu
DOI: 10.2741/4754 Published: 01 March 2019
Open Access
Article

Baicalein exerts a protective role in pneumonia caused by Streptococcus pneumoniae

Guo Qinghe, Liu Guangyu, Liu Xiaobin, Huang Qingsong
Frontiers in Bioscience-Landmark Volume 24 Issue 5, pp.849-858
Managing Editor: Li Liu
DOI: 10.2741/4755 Published: 01 March 2019
Open Access
Article

Higenamine alleviates cerebral ischemia-reperfusion injury in rats

Xiaoping Wang, Xiaojia Li, Wu Jingfen, Deng Fei, Peng Mei
Frontiers in Bioscience-Landmark Volume 24 Issue 5, pp.859-869
Managing Editor: Li Liu
DOI: 10.2741/4756 Published: 01 March 2019
Open Access
Review

How biological elements interact with language: The biolinguistic inquiry

Tiaoyuan Mao, Zaijiang Man, Huaping Lin, Caimei Yang
Frontiers in Bioscience-Landmark Volume 25 Issue 5, pp.930-947
Managing Editor: Li Liu
DOI: 10.2741/4841 Published: 01 January 2020
Open Access
Review

CUEDC2: multifunctional roles in carcinogenesis

Jun-bo Xiao, Ai-min Leng, Yan-qiu Zhang, Zhen Wen, Jian He, Guan-nan Ye
Frontiers in Bioscience-Landmark Volume 24 Issue 5, pp.935-946
Managing Editor: Li Liu
DOI: 10.2741/4759 Published: 01 March 2019
Open Access
Article

PCAT1/miR-129/ABCB1 axis confers chemoresistance in non-small cell lung cancer

Ruifen Tian, Congjun Zhang, Fuxing Xiong, Huanwen Chen
Frontiers in Bioscience-Landmark Volume 25 Issue 5, pp.948-960
Managing Editor: Li Liu
DOI: 10.2741/4842 Published: 01 March 2020
Open Access
Article

The antitumor effect of resveratrol on nasopharyngeal carcinoma cells

Huisheng Xiong, Jun Cheng, Shen Jiang, Jun Wen, Yang Jian, Lu Wei, Zhang Zhe, Jiang Fu-qiang, Xie Peng
Frontiers in Bioscience-Landmark Volume 24 Issue 5, pp.961-970
Managing Editor: Li Liu
DOI: 10.2741/4761 Published: 01 March 2019
Open Access
Article

Characterization of structural requirement for binding of gigantol and aldose reductase

Yong Yang, Qiaohong Yang, Juan Yu, Wencheng Wan, Xiaoyong Wei
Frontiers in Bioscience-Landmark Volume 24 Issue 6, pp.1024-1036
Managing Editor: Li Liu
DOI: 10.2741/4765 Published: 01 March 2019
Open Access
Article

BMP4 inhibits glioblastoma invasion by promoting E-cadherin and claudin expression

Xiangdong Zhao, Qian Sun, Changwu Dou, Qianxue Chen, Baohui Liu
Frontiers in Bioscience-Landmark Volume 24 Issue 6, pp.1060-1070
Managing Editor: Li Liu
DOI: 10.2741/4768 Published: 01 March 2019
Open Access
Article

Interactions between human hemoglobin subunits and peroxiredoxin 2

Qiang Ma, Liang An, Huifang Tian, Jia Liu, Liqiang Zhang, Xiaojing Li, Chunhua Wei, Caixia Xie, Huirong Ding, Wenbin Qin, Yan Su
Frontiers in Bioscience-Landmark Volume 24 Issue 6, pp.1085-1096
Managing Editor: Li Liu
DOI: 10.2741/4770 Published: 01 March 2019
Open Access
Article

Bioactivity and safety of chimeric switch receptor T cells in glioblastoma patients

Jun-Xiu Guo, Chen-Xing Wu, Peng-fei Wang, Zhong-Jun Li, Song Han, Wen Jin, Zhi-Xiong Lin
Frontiers in Bioscience-Landmark Volume 24 Issue 6, pp.1158-1166
Managing Editor: Li Liu
DOI: 10.2741/4772 Published: 01 June 2019
Open Access
Article

miR-139 inhibits osteosarcoma cell proliferation and invasion by targeting ROCK1

Gentao Fan, Zhiwei He, Lili Cao, Xin Shi, Sujia Wu, Guangxin Zhou
Frontiers in Bioscience-Landmark Volume 24 Issue 6, pp.1167-1177
Managing Editor: Li Liu
DOI: 10.2741/4773 Published: 01 June 2019
Open Access
Article

Asporin promotes cell proliferation via interacting with PSMD2 in gastric cancer

Zheng Zhang, Hengcun Li, Yu Zhao, Qingdong Guo, Yang Yu, Shengtao Zhu, Shutian Zhang, Li Min, Peng Li
Frontiers in Bioscience-Landmark Volume 24 Issue 6, pp.1178-1189
Managing Editor: Li Liu
DOI: 10.2741/4774 Published: 01 June 2019
Open Access
Review
NOK mediated mitogenic signaling is altered by P203L and V395I mutations
Sheng-Qi Hou, Li Liu
Frontiers in Bioscience-Landmark Volume 20 Issue 7, pp.1179-1189
Managing Editor: Li Liu
DOI: 10.2741/4366 Published: 01 June 2015
Open Access
Article

Berberine enhances the radiosensitivity of hepatoma cells by Nrf2 pathway

Xiaojing You, Xuezhen Cao, Yucheng Lin
Frontiers in Bioscience-Landmark Volume 24 Issue 7, pp.1190-1202
Managing Editor: Li Liu
DOI: 10.2741/4775 Published: 01 June 2019
Open Access
Article

Cord blood CD4+/CD25+ T cells down-regulates NKG2D on cytokine-induced killer cells

Aihua Liu, Qian Wang, Xianyong Yang, Shaohua Shen, Yuzhen Xu
Frontiers in Bioscience-Landmark Volume 24 Issue 7, pp.1259-1270
Managing Editor: Li Liu
DOI: 10.2741/4778 Published: 01 June 2019
Open Access
Article

MicroRNA-22 regulates thyroid cell growth and lipid accumulation via IL6R

Zaiyou Dai, Haihong Yan, Kangyao Wang, Sen Zhong, Min Zhou, Dan Zheng, Huiping Zhu
Frontiers in Bioscience-Landmark Volume 24 Issue 8, pp.1350-1362
Managing Editor: Li Liu
DOI: 10.2741/4783 Published: 01 June 2019
Open Access
Article

RICH2, a potential tumor suppressor in hepatocellular carcinoma

Jiarui Zhang, Chen Yang, Li Gong, Shaojun Zhu, Jing Tian, Fuqin Zhang, Qiao Zhu, Jun Wang, Miao Lan, Yanhong Li, Wei Zhang
Frontiers in Bioscience-Landmark Volume 24 Issue 8, pp.1363-1376
Managing Editor: Li Liu
DOI: 10.2741/4784 Published: 01 June 2019
Open Access
Article

miR-21 regulates growth and EMT in lung cancer cells via PTEN/Akt/GSK3β signaling

Lihua Dai, Fenghua Chen, Yonghua Zheng, Ding Zhang, Bao Qian, Huaxia Ji, Feng Long, Dragos Cretoiu
Frontiers in Bioscience-Landmark Volume 24 Issue 8, pp.1426-1439
Managing Editor: Li Liu
DOI: 10.2741/4788 Published: 01 June 2019
Open Access
Article

Resveratrol enhances chemosensitivity of renal cell carcinoma to paclitaxel

Ke Ying-jie, Chen Ling-wei, Zhou Min, Guo Jia-ping, Wang Ying, Zheng Dan, Zhong Sen
Frontiers in Bioscience-Landmark Volume 24 Issue 8, pp.1452-1461
Managing Editor: Li Liu
DOI: 10.2741/4790 Published: 01 June 2019
Open Access
Article

Qi-dan-di-huang decoction alleviates diabetic nephropathy by inhibiting the NF-kappaB pathway

Fei Ma, Lingxing Li, Qian Wang, Zujiang Chen, Yanting You, Peiping Gao, Xiaoshan Zhao, Ren Luo
Frontiers in Bioscience-Landmark Volume 24 Issue 8, pp.1477-1486
Managing Editor: Li Liu
DOI: 10.2741/4792 Published: 01 June 2019
Open Access
Article

Progression of squamous cell carcinoma is regulated by miR-139-5p/CXCR4

Qian Jiang, Yiting Cao, Yating Qiu, Chenlin Li, Liu Liu, Guangzhou Xu
Frontiers in Bioscience-Landmark Volume 25 Issue 9, pp.1732-1745
Managing Editor: Li Liu
DOI: 10.2741/4875 Published: 01 June 2020
Open Access
Article

MEG3 targets miR-184 and Wnt/β-catenin and modulates properties of osteosarcoma

Liang Li, SiBiao Pei, Na Sun
Frontiers in Bioscience-Landmark Volume 25 Issue 10, pp.1901-1912
Managing Editor: Li Liu
DOI: 10.2741/4884 Published: 01 June 2020
Open Access
Article

Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP/PCG-1α and pERK1/2

Kaijian Hou, Yongru Chen, Dan Zhu, Genben Chen, Fengwu Chen, Ningning Xu, Khan Barkat, Jiehong Zheng, Xi Xie, Rongping Chen
Frontiers in Bioscience-Landmark Volume 25 Issue 11, pp.1974-1984
Managing Editor: Li Liu
DOI: 10.2741/4887 Published: 01 June 2020