Open Access

Role of the store-operated Ca2+ channel in ATP-induced Ca2+ signalling in mesenchymal stem cells and regulation of cell functions

Lu Wang1,Sébastien Roger2,Xuebin B Yang3,Lin-Hua Jiang1,4,*
Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Xinxiang Medical University, 453003 Xinxiang, Henan, China
EA4245-Transplantation, Immunology and Inflammation, Faculty of Medicine, University of Tours, 37032 Tours, France
Division of Oral Biology, University of Leeds, Welcome Trust Brenner Building, LS9 7TF Leeds, UK
School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, LS2 9JT Leeds, UK
DOI: 10.52586/5065 Volume 26 Issue 12, pp.1737-1745
Submited: 16 September 2021 Revised: 13 October 2021
Accepted: 22 October 2021 Published: 30 December 2021
*Corresponding Author(s):  
Lin-Hua Jiang
Copyright: © 2021 The author(s). Published by BRI. This is an open access article under the CC BY 4.0 license (

It is well-known that extracellular ATP acts as an autocrine/paracrine signal to regulate cell functions by inducing intracellular Ca2+ signalling through its cognate receptors, namely, the ligand-gated ion channel P2X receptors that mediate Ca2+ influx and/or the Gq/11q/11-coupled P2Y receptors that link to Ca2+ release from the ER. The reduction in ER Ca2+ can trigger further extracellular Ca2+ entry by activating the store-operated Ca2+ (SOC) channel. Mesenchymal stem cells (MSC) play an important role in the homeostasis of residing tissues and have promising applications in regenerative medicines. MSC can release ATP spontaneously or in response to diverse stimuli, and express multiple P2X and Gq/11-coupled P2Y receptors that participate in ATP-induced Ca2+ signalling and regulate cell function. There is increasing evidence to show the contribution of the SOC channel in ATP-induced Ca2+ signalling in MSC. In this mini-review, we discuss the current understanding of the expression of the SOC channel in MSC and its potential role in mediating ATP-induced Ca2+ signalling and regulation of MSC differentiation, proliferation and migration.

Key words

Mesenchymal stem cells; Extracellular ATP; Ca2+ signalling; Store-operated Ca2+ channel

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Lu Wang, Sébastien Roger, Xuebin B Yang, Lin-Hua Jiang. Role of the store-operated Ca2+ channel in ATP-induced Ca2+ signalling in mesenchymal stem cells and regulation of cell functions. Frontiers in Bioscience-Landmark. 2021. 26(12); 1737-1745.