Open Access
Review

Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target

Di Long1,Kai Chen1,Yinmo Yang1,*,Xiaodong Tian1,*
1
Department of General Surgery, Peking University First Hospital, 100034 Beijing, China
DOI: 10.52586/5061 Volume 26 Issue 12, pp.1689-1696
Submited: 12 September 2021 Revised: 13 October 2021
Accepted: 28 October 2021 Published: 30 December 2021
*Corresponding Author(s):  
Yinmo Yang
E-mail:  
YangyinmoSCI@bjmu.edu.cn
*Corresponding Author(s):  
Xiaodong Tian
E-mail:  
tianxiaodong@pkufh.com
Copyright: © 2021 The author(s). Published by BRI. This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract

Pancreatic cancer is still one of the most perilous malignant tumors with a very poor prognosis. Despite the progress in the diagnosis and treatment of pancreatic cancer, the overall 5-year survival rate after diagnosis is less than 10%. The pathogenesis of pancreatic cancer has not been fully clarified, but multiple factors are involved. The poor efficacy of traditional therapies for pancreatic cancer is mainly related to complex tumor microenvironment. In recent years, accumulating studies have demonstrated the role of autophagy and apoptosis triggered by endoplasmic reticulum stress in pancreatic cancer. In particular, unfolded protein response is activated by endoplasmic reticulum stress and plays an important role in the modulation of complex pancreatic tumor microenvironment. Here we summarize recent progress in our understanding of the role of unfolded protein response activated by endoplasmic reticulum stress in tumorigenesis of pancreatic cancer, and highlight the potential of the cascade of unfolded protein response as therapeutic target for pancreatic cancer.

Key words

Endoplasmic reticulum stress; Unfolded pro-tein response; Pancreatic cancer; Apoptosis

Share and Cite
Di Long, Kai Chen, Yinmo Yang, Xiaodong Tian. Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target. Frontiers in Bioscience-Landmark. 2021. 26(12); 1689-1696.