Open Access

Pathways in small cell lung cancer and its therapeutic perspectives

Pingali M. Shivapriya1,Anirudh Singh1,Priyanshu Pandey2,Nandini Chhabra3,Amaresh Kumar Sahoo1,Biswaranjan Paital4,*,Pritish Kumar Varadwaj1,*,Sintu Kumar Samanta1,*
Department of Applied Sciences, Indian Institute of Information Technology Allahabad, 211012 Allahabad, India
Department of Biotechnology, National Institute of Technology Durgapur, 713209 Durgapur, West Bengal, India
Department of Studies in Biotechnology, University of Mysore, 570005 Mysore, Karnataka, India
Redox Regulation Laboratory, Department of Zoology, Odisha University of Agriculture and Technology, College of Basic Science and Humanities, 751003 Bhubaneswar, Odisha, India
DOI: 10.52586/5059 Volume 26 Issue 12, pp.1668-1678
Submited: 07 July 2021 Revised: 16 November 2021
Accepted: 23 November 2021 Published: 30 December 2021
*Corresponding Author(s):  
Biswaranjan Paital
*Corresponding Author(s):  
Pritish Kumar Varadwaj
*Corresponding Author(s):  
Sintu Kumar Samanta
Copyright: © 2021 The author(s). Published by BRI. This is an open access article under the CC BY 4.0 license (

Small cell lung cancer (SCLC) is known for its rapid growth with high metastatic spread. Its treatment remains a major challenge for oncologists due to the high mutation rate and other clinical disadvantages. The survival rate of these patients is very poor but there is no significant progress over the last few decades in the treatment protocols. Hence there is an urgency to design new clinical trials with novel drug combinations that can specifically and effectively target key pathways for proper treatment of SCLC. There have been several indications that developmental signalling pathways are involved in tumor growth, progression, metastasis and invasion of SCLC. Thus, it is anticipated that deciphering the signalling cascades of these embryonic signalling pathways may reveal novel therapeutic breakthroughs in SCLC. In this context, we have tried to assemble all the relevant information to give an updated overview of the various signalling pathways involved in the development of SCLC.

Key words

Small cell lung cancer; Therapeutics; Sig-nalling pathways; Notch pathway; FGF pathway; Hedge-hog pathway

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Pingali M. Shivapriya, Anirudh Singh, Priyanshu Pandey, Nandini Chhabra, Amaresh Kumar Sahoo, Biswaranjan Paital, Pritish Kumar Varadwaj, Sintu Kumar Samanta. Pathways in small cell lung cancer and its therapeutic perspectives. Frontiers in Bioscience-Landmark. 2021. 26(12); 1668-1678.