Open Access
Editorial

Amino acids in nutrition, health, and disease

Guoyao Wu1,*
1
Department of Animal Science, Texas A&M University, College Station, TX 77843, USA
DOI: 10.52586/5032 Volume 26 Issue 12, pp.1386-1392
Submited: 24 November 2021 Revised: 08 December 2021
Accepted: 10 December 2021 Published: 30 December 2021
*Corresponding Author(s):  
Guoyao Wu
E-mail:  
g-wu@tamu.edu
Copyright: © 2021 The author(s). Published by BRI. This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
References

[1] Wu G. Amino Acids: Biochemistry and Nutrition. 2nd edn. CRC Press: Boca Raton, Florida. 2021.

[2] Marc Rhoads J, Wu G. Glutamine, arginine, and leucine signaling in the intestine. Amino Acids. 2009; 37: 111–122.

[3] Phang JM, Liu W, Zabirnyk O. Proline metabolism and microenvironmental stress. Annual Review of Nutrition. 2010; 30: 441–463.

[4] Bröer S, Bröer A. Amino acid homeostasis and signalling in mammalian cells and organisms. The Biochemical Journal. 2017; 474: 1935–1963.

[5] Hobbach AJ, Closs EI. Human cationic amino acid transporters are not affected by direct nitros(yl)ation. Amino Acids. 2020; 52: 499–503.

[6] Agostinelli E. Biochemical and pathophysiological properties of polyamines. Amino Acids. 2020; 52: 111–117.

[7] Neu A, Hornig S, Sasani A, Isbrandt D, Gerloff C, Tsikas D, et al. Creatine, guanidinoacetate and homoarginine in statin-induced myopathy. Amino Acids. 2020; 52: 1067–1069.

[8] Tsikas D, Bollenbach A, Hanff E, Beckmann B, Redfors B. Synthesis of homoagmatine and GC–MS analysis of tissue homoagmatine and agmatine: evidence that homoagmatine but not agmatine is a metabolite of pharmacological L-homoarginine in the anesthetized rat. Amino Acids. 2020; 52: 235–245.

[9] Manjarín R, Boutry-Regard C, Suryawan A, Canovas A, Piccolo BD, Maj M, et al. Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs. Amino Acids. 2020; 52: 1319–1335.

[10] Beaumont M, Blachier F. Amino acids in intestinal physiology and health. Advances in Experimental Medicine and Biology. 2020; 1265: 1–20.

[11] Bringaud F, Barrett MP, Zilberstein D. Multiple roles of proline transport and metabolism in trypanosomatids. Frontiers in Bioscience (Landmark Edition). 2012; 17: 349–374.

[12] Singh RK, Tanner JJ. Unique structural features and sequence motifs of proline utilization a (PutA). Frontiers in Bioscience (Landmark Edition). 2012; 17: 556–568.

[13] Arentson BW, Sanyal N, Becker DF. Substrate channeling in proline metabolism. Frontiers in Bioscience (Landmark Edition). 2012; 17: 375–388.

[14] Servet C, Ghelis T, Richard L, Zilberstein A, Savoure A. Proline dehydrogenase: a key enzyme in controlling cellular homeostasis. Frontiers in Bioscience (Landmark Edition). 2012; 17: 607–620.

[15] Jung H, Hilger D, Raba M. The Na+/L-proline transporter PutP. Frontiers in Bioscience (Landmark Edition). 2012; 17: 745–759.

[16] Phang JM, Liu W. Proline metabolism and cancer. Frontiers in Bioscience (Landmark Edition). 2012; 17: 1835–1845.

[17] Liao SF, Regmi N, Wu G. Homeostatic regulation of plasma amino acid concentrations. Frontiers in Bioscience (Landmark Edition). 2018; 23: 640–655.

[18] Suryawan A, Davis TA. Regulation of protein synthesis by amino acids in muscle of neonates. Frontiers in Bioscience (Landmark Edition). 2011; 16: 1445–1460.

[19] Xi P, Jiang Z, Zheng C, Lin Y, Wu G. Regulation of protein metabolism by glutamine: implications for nutrition and health. Frontiers in Bioscience (Landmark Edition). 2011; 16: 578–597.

[20] Tan B, Li X, Yin Y, Wu Z, Liu C, Tekwe CD, et al. Regulatory roles for L-arginine in reducing white adipose tissue. Frontiers in Bioscience (Landmark Edition). 2012; 17: 2237–2246.

[21] Lei J, Feng D, Zhang Y, Zhao F, Wu Z, San Gabriel A, et al. Nutritional and regulatory role of branched-chain amino acids in lactation. Frontiers in Bioscience (Landmark Edition). 2012; 17: 2725–2739.

[22] Tan B, Xiao H, Xiong X, Wang J, Li G, Yin Y, et al. L-arginine improves DNA synthesis in LPS-challenged enterocytes. Frontiers in Bioscience (Landmark Edition). 2015; 20: 989–1003.

[23] Duan Y, Li F, Liu H, Li Y, Liu Y, Kong X, et al. Nutritional and regulatory roles of leucine in muscle growth and fat reduction. Frontiers in Bioscience (Landmark Edition). 2015; 20: 796–813.

[24] Zhao F. Octamer-binding transcription factors: genomics and functions. Frontiers in Bioscience (Landmark Edition). 2013; 18: 1051–1071.

[25] Newsholme P, Abdulkader F, Rebelato E, Romanatto T, Pinheiro CHJ, Vitzel KF, et al. Amino acids and diabetes: implications for endocrine, metabolic and immune function. Frontiers in Bioscience (Landmark Edition). 2011; 16: 315–339.

[26] Gao H, Ho E, Yallampalli C. Ghrelin doesn’t limit insulin release in pregnant rats fed low protein diet. Frontiers in Bioscience (Landmark Edition). 2017; 22: 1523–1533.

[27] Satterfield MC, Wu G. Brown adipose tissue growth and development: significance and nutritional regulation. Frontiers in Bioscience (Landmark Edition). 2011; 16: 1589–1608.

[28] Wang T, Liu C, Feng C, Wang X, Lin G, Zhu Y, et al. IUGR alters muscle fiber development and proteome in fetal pigs. Frontiers in Bioscience (Landmark Edition). 2013; 18: 598–607.

[29] Zhu C, Jiang Z, Bazer FW, Johnson GA, Burghardt RC, Wu G. Aquaporins in the female reproductive system of mammals. Frontiers in Bioscience (Landmark Edition). 2015; 20: 838–871.

[30] Dai Z, Wu G, Zhu W. Amino acid metabolism in intestinal bacteria: links between gut ecology and host health. Frontiers in Bioscience (Landmark Edition). 2011; 16: 1768–1786.

[31] Blachier F, Davila AM, Benamouzig R, Tome D. Channelling of arginine in no and polyamine pathways in colonocytes and consequences. Frontiers in Bioscience (Landmark Edition). 2011; 16: 1331–1343.

[32] Hou Y, Wang L, Ding B, Liu Y, Zhu H, Liu J, et al. Alpha-Ketoglutarate and intestinal function. Frontiers in Bioscience (Landmark Edition). 2011; 16: 1186–1196.

[33] Wu X, Zhang Y, Yin Y, Ruan Z, Yu H, Wu Z, et al. Roles of heat-shock protein 70 in protecting against intestinal mucosal damage. Frontiers in Bioscience (Landmark Edition). 2013; 18: 356–365.

[34] Wang L, Hou Y, Yi D, Ding B, Zhao D, Wang Z, et al. Beneficial roles of dietary oleum cinnamomi in alleviating intestinal injury. Frontiers in Bioscience (Landmark Edition). 2015; 20: 814–828.

[35] Hou YQ, Wang L, Yi D, Wu G. N-Acetylcysteine and intestinal health: a focus on mechanisms of its actions. Frontiers in Bioscience (Landmark Edition). 2015; 20: 872–891.

[36] Yi D, Hou Y, Wang L, Zhao D, Ding B, Wu T, et al. Gene expression profiles in the intestine of lipopolysaccharide-challenged piglets. Frontiers in Bioscience (Landmark Edition). 2016; 21: 487–501.

[37] Hou Y. Trilactic glyceride regulates lipid metabolism and improves gut function in piglets. Frontiers in Bioscience (Landmark Edition). 2020; 25: 1324–1336.

[38] He Q, Yin Y, Zhao F, Kong X, Wu G, Ren P. Metabonomics and its role in amino acid nutrition research. Frontiers in Bioscience (Landmark Edition). 2011; 16: 2451–2460.

[39] Wu F, Xiong X, Yang H, Yao K, Duan Y, Wang X, et al. Expression of proteins in intestinal middle villus epithelial cells of weaning piglets. Frontiers in Bioscience (Landmark Edition). 2017; 22: 539–557.

[40] Xiong X, Yang H, Hu X, Wang X, Li B, Long L, et al. Differential proteome analysis along jejunal crypt-villus axis in piglets. Frontiers in Bioscience (Landmark Edition). 2016; 21: 343–363.

[41] He L, Yin Y, Li T, Huang R, Xie M, Wu Z, et al. Use of the Ussing chamber technique to study nutrient transport by epithelial tissues. Frontiers in Bioscience (Landmark Edition). 2013; 18: 1266–1274.

[42] Assaad H, Yao K, Tekwe CD, Feng S, Bazer FW, Zhou L, et al. Analysis of energy expenditure in diet-induced obese rats. Frontiers in Bioscience (Landmark Edition). 2014; 19: 967–985.

[43] Wu T, Lv Y, Li X, Zhao D, Yi D, Wang L, et al. Establishment of a recombinant Escherichia coli-induced piglet diarrhea model. Frontiers in Bioscience (Landmark Edition). 2018; 23: 1517–1534.

[44] Yi D, Liu W, Hou Y, Wang L, Zhao D, Wu T, et al. Establishment of a porcine model of indomethacin-induced intestinal injury. Frontiers in Bioscience (Landmark Edition). 2018; 23: 2166–2176.

[45] Lee U, Garcia TP, Carroll RJ, Gillbreath KP, Wu G. Analysis of repeated measures data in nutrition research. Frontiers in Bioscience (Landmark Edition). 2019; 24: 1377–1389.

[46] Le Floc’h N, Wessels A, Corrent E, Wu G, Bosi P. The relevance of functional amino acids to support the health of growing pigs. Animal Feed Science and Technology. 2018; 245: 104–116.

[47] Zhang Q, Hou Y, Bazer FW, He W, Posey EA, Wu G. Amino acids in swine nutrition and production. Advances in Experimental Medicine and Biology. 2021; 1285: 81–107.

[48] Zhu C, Li X, Bazer FW, Johnson GA, Burghardt RC, Jiang Z, et al. Dietary L-arginine supplementation during days 14–25 of gestation enhances aquaporin expression in the placentae and endometria of gestating gilts. Amino Acids. 2021; 53: 1287–1295.

[49] Bergen WG. Amino acids in beef cattle nutrition and production. Advances in Experimental Medicine and Biology. 2021; 1285: 29–42.

[50] Gilbreath KR, Bazer FW, Satterfield MC, Wu G. Amino acid nutrition and reproductive performance in ruminants. Advances in Experimental Medicine and Biology. 2021; 1285: 43–61.

[51] Cao Y, Yao J, Sun X, Liu S, Martin GB. Amino acids in the nutrition and production of sheep and goats. Advances in Experimental Medicine and Biology. 2021; 1285: 63–79.

[52] Satterfield MC, Edwards AK, Bazer FW, Dunlap KA, Steinhauser CB, Wu G. Placental adaptation to maternal malnutrition. Reproduction. 2021; 162: R73–R83.

[53] McKnight SM, Simmons RM, Wu G, Satterfield MC. Maternal arginine supplementation enhances thermogenesis in the newborn lamb. Journal of Animal Science. 2020; 98: skaa118.

[54] Sales F, Sciascia Q, van der Linden DS, Wards NJ, Oliver MH, McCoard SA. Intravenous maternal arginine administration to twin-bearing ewes, during late pregnancy, is associated with increased fetal muscle mTOR abundance and postnatal growth in twin female lambs. Journal of Animal Science. 2016; 94: 2519–2531.

[55] He W, Li P, Wu G. Amino acid nutrition and metabolism in chickens. Advances in Experimental Medicine and Biology. 2021; 52: 109–131.

[56] He W, Furukawa K, Toyomizu M, Nochi T, Bailey CA, Wu G. Interorgan metabolism, nutritional impacts, and safety of dietary L-glutamate and L-glutamine in poultry. Advances in Experimental Medicine and Biology. 2021; 1332: 107–128.

[57] Furukawa K, He W, Bailey CA, Bazer FW, Toyomizu M, Wu G. Polyamine synthesis from arginine and proline in tissues of developing chickens. Amino Acids. 2021; 53: 1739–1748.

[58] Li X, Zheng S, Wu G. Nutrition and metabolism of glutamate and glutamine in fish. Amino Acids. 2020; 52: 671–691.

[59] Li X, Shixuan Zheng, Jia S, Song F, Zhou C, Wu G. Oxidation of energy substrates in tissues of largemouth bass (Micropterus salmoides). Amino Acids. 2020; 52: 1017–1032.

[60] Li XY, Zheng SX, Ma XK, Cheng KM, Wu G. Effects of dietary protein and lipid levels on growth performance, feed utilization, and liver histology of largemouth bass (Micropterus salmoides). Amino Acids. 2020; 52: 1043-1061.

[61] Li X, Zheng S, Ma X, Cheng K, Wu G. Effects of dietary starch and lipid levels on the protein retention and growth of largemouth bass (Micropterus salmoides). Amino Acids. 2020; 52: 999–1016.

[62] Li X, Zheng S, Wu G. Nutrition and functions of amino acids in fish. Advances in Experimental Medicine and Biology. 2021; 1285: 133–168.

[63] Palomino Ramos AR, Campelo DAV, Carneiro CLDS, Zuanon JAS, da Matta SLP, Furuya WM, et al. Optimal dietary Lglutamine level improves growth performance and intestinal histomorphometry of juvenile giant trahira (Hoplias lacerdae), a Neotropical carnivorous fish species. Aquaculture. 2022; 547: 737469.

[64] Li X, Han T, Zheng S, Wu G. Nutrition and functions of amino acids in aquatic crustaceans. Advances in Experimental Medicine and Biology. 2021; 1285: 169–198.

[65] Wu G. Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health. Amino Acids. 2020; 52: 329–360.

[66] Ogilvie AR, Watford M, Wu G, Sukumar D, Kwon J, Shapses SA. Decreased glucogenic amino acids with a higher compared to normal protein diet during energy restriction in women: a randomized controlled trial. Amino Acids. 2021; 53: 1467–1472.

[67] Wu G, Meininger CJ, McNeal CJ, Bazer FW, Rhoads JM. Role of L-arginine in nitric oxide synthesis and health in humans. Advances in Experimental Medicine and Biology. 2021; 1332: 167–187.

[68] Dai Z, Wu Z, Zhu W, Wu G. Amino acids in microbial metabolism and function. Advances in Experimental Medicine and Biology. 2022; 1354: 127–143.

[69] Mu C, Pi Y, Zhang C, Zhu W. Microbiomes in the intestine of developing pigs: Implications for nutrition and health. Advances in Experimental Medicine and Biology. 2022; 1354: 161–176.

[70] Patel SM, Seravalli J, Stiers KM, Tanner JJ, Becker DF. Kinetics of human pyrroline-5-carboxylate reductase in L-thioproline metabolism. Amino Acids. 2021; 53: 1863–1874.

[71] Phang JM. Proline metabolism in cell regulation and cancer biology: Recent advances and hypotheses. Antioxidants & Redox Signaling. 2019; 30: 635–649.

[72] Geng P, Qin W, Xu G. Proline metabolism in cancer. Amino Acids. 2021; 53: 1769–1777.

[73] Hou Y, He W, Hu S, Wu G. Composition of polyamines and amino acids in plant-source foods for human consumption. Amino Acids. 2019; 51: 1153–1165.

[74] Li P, Wu G. Composition of amino acids and related nitrogenous nutrients in feedstuffs for animal diets. Amino Acids. 2020; 52: 523–542.

[75] Li P, Wu G. Functional molecules of intestinal mucosal products in animal nutrition and health. Advances in Experimental Medicine and Biology. 2022; 1354: 263–277.

[76] Li P, Wu G. Important roles of amino acids in immune responses. The British Journal of Nutrition. 2021. (in press)

Share and Cite
Guoyao Wu. Amino acids in nutrition, health, and disease. Frontiers in Bioscience-Landmark. 2021. 26(12); 1386-1392.