Open Access
Article
Immunotherapy of human papillomavirus-associated malignancies and the challenges posed by T-cell tolerance
Ryan A Wilcox1,Lieping Chen1
1
Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
DOI: 10.2741/wilcox Volume 7 Issue 4, pp.853-871
Published: 01 April 2002
(This article belongs to the Special Issue Papillomaviruses: immunology and vaccines)
Abstract

Human papillomaviruses are associated with a broad range of carcinomas, including cervical cancer. Although the delivery of immunogenic tumor-associated antigens represents a promising approach in the treatment of these malignancies, the imposition of T cell tolerance poses a significant challenge in this endeavor. The purpose of this review is to discuss T cell tolerance and the role of T cell costimulation in the immunotherapy of HPV-associated malignancies.

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Ryan A Wilcox, Lieping Chen. Immunotherapy of human papillomavirus-associated malignancies and the challenges posed by T-cell tolerance. Frontiers in Bioscience-Landmark. 2002. 7(4); 853-871.