Open Access
Article
Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA
B S Skalhegg1,K Tasken1
1
Institute for Nutrition Reserarch, University of Oslo, Norway. bjorn.skalhegg@basalmed.uio.no
DOI: 10.2741/skalhegg Volume 5 Issue 3, pp.678-693
Published: 01 August 2000
(This article belongs to the Special Issue Signaling through protein kinase C)
Abstract

A large number of hormones, neurotransmitters and other signal substances utilize adenosine 3',5' cyclic monophosphate (cAMP) as an intracellular second messenger. Cyclic AMP regulates a number of different cellular processes such as cell growth and differentiation, ion channel conductivity, synaptic release of neurotransmitters, and gene transcription. The principle intracellular target for cAMP in mammalian cells is the cAMP-dependent protein kinase (PKA). The fact that this broad specificity protein kinase mediates a number of discrete physiological responses following cAMP-engagement, has raised the question of how specificity is maintained in the cAMP/PKA system. Here we will describe features of this signaling pathway that may contribute to explain how differential effects of cAMP may be contributed to features of the PKA signaling pathway.

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B S Skalhegg, K Tasken. Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA. Frontiers in Bioscience-Landmark. 2000. 5(3); 678-693.