Open Access
Interactions of HIV-1 NEF with cellular signal transducing proteins
G H Renkema1,K Saksela1
Institute of Medical Technology, University of Tampere, FIN-33101, Tampere, Finland
DOI: 10.2741/renkema Volume 5 Issue 3, pp.268-283
Published: 01 February 2000
(This article belongs to the Special Issue New and emerging targets for antiviral therapy)

Nef is a 27 - 34 kD myristoylated protein unique to primate lentiviruses. A functional Nef gene is important for development of high viremia and simian AIDS in SIV infected rhesus macaques (1). In a transgenic mouse model expression of Nef protein alone when expressed under a CD4-promoter is sufficient to cause an AIDS like disease (2). A critical role for Nef in development of AIDS in humans is suggested by the observation that some individuals with a long-term nonprogressive HIV-1 infection are infected with viruses carrying naturally occurring Nef deletions (3-5). The mechanism of Nef action remains incompletely understood, but multiple lines of evidence point out to a role in modulation of cellular signaling pathways via physical and functional interactions with host cell proteins.

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G H Renkema, K Saksela. Interactions of HIV-1 NEF with cellular signal transducing proteins. Frontiers in Bioscience-Landmark. 2000. 5(3); 268-283.