Open Access
Immune regulation by CD40-CD40-l interactions - 2; Y2K update
C van Kooten1
Dept of Nephrology, Leiden University Medical Center, Leiden, the Netherlands
DOI: 10.2741/kooten Volume 5 Issue 3, pp.880-693
Published: 01 November 2000

CD40 is a cell surface receptor, which belongs to the TNF-R family, and which was first identified and functionally characterized on B lymphocytes. However, in recent years it has become clear that CD40 is expressed much broader, including expression on monocytes, dendritic cells, endothelial cells and epithelial cells. Therefore it is now thought that CD40 plays a more general role in immune regulation. The present paper reviews recent developments in this field of research, with main emphasis on CD40 signal transduction and on in vivo functions of CD40/CD40-L interactions.

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C van Kooten. Immune regulation by CD40-CD40-l interactions - 2; Y2K update. Frontiers in Bioscience-Landmark. 2000. 5(3); 880-693.