Open Access
The KSHV latency-associated nuclear antigen: a multifunctional protein
Takashi Komatsu1,Mary E Ballestas1,Andrew J Barbera1,Kenneth M Kaye1
Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Ave., Boston, MA 021115, USA
DOI: 10.2741/komatsu Volume 7 Issue 4, pp.726-730
Published: 01 March 2002
(This article belongs to the Special Issue DNA viruses and human malignancies)

Kaposi's sarcoma(KS)-associated herpes virus (KSHV) or human herpesvirus 8 (HHV-8) is highly associated with KS, primary effusion lymphoma (PEL), and multicentric Castleman's disease, an aggressive lymphoproliferative disorder (1-3). Most tumor cells are latently infected with KSHV in which a small subset of viral genes are expressed (4-6). Of these latently expressed genes, the latency-associated nuclear antigen (LANA1, LNA, or LNA1) is the only protein consistently shown to be highly expressed by in situ hybridization and immunohistochemistry (7-10). In the past few years multiple functions have been demonstrated for LANA1. Here we review LANA1's roles in KSHV infection. Topics discussed include LANA1's roles in episome persistence, regulation of transcription and interaction with cellular proteins.

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Takashi Komatsu, Mary E Ballestas, Andrew J Barbera, Kenneth M Kaye. The KSHV latency-associated nuclear antigen: a multifunctional protein. Frontiers in Bioscience-Landmark. 2002. 7(4); 726-730.