Open Access
Article
Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival
Steven Grant1,Liang Qiao1,Paul Dent1
1
Department of Hematology/Oncology, Medical College of Virginia,Virginia Commonwealth University, Richmond, VA 23298-0058, USA
DOI: 10.2741/grant Volume 7 Issue 4, pp.376-389
Published: 01 February 2002
(This article belongs to the Special Issue Biology and medicine of ErbB tyrosine kinases)
Abstract

Within the last 20 years, multiple novel intracellular signal transduction pathways, downstream of plasma membrane receptors, have been discovered. These pathways have been linked to the regulation of diverse cellular events such as proliferation, senescence, differentiation and apoptosis. This review will focus upon the roles of signaling by the ErbB receptor tyrosine kinase family (ErbB1-4) in the survival of cells in response to cytotoxic stresses. In addition, plasma membrane-to-nucleus signaling pathways downstream of these receptors, such as mitogen activated protein kinase (MAPK) and phosphatidyl inositol 3-kinase (PI3K), in the control of cell survival will be discussed. Recent evidence suggests that signaling by the MAPK and PI3K pathways can both enhance proliferation as well as protect cells from apoptosis. We describe potential mechanisms by which modulation of pathway activities following inhibition of ErbB receptor function may alter the sensitivity of cells to toxic insults, leading to increased apoptosis and loss of clonogenic survival.

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Steven Grant, Liang Qiao, Paul Dent. Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival. Frontiers in Bioscience-Landmark. 2002. 7(4); 376-389.