Open Access
Lipoprotein lipase: physiology, biochemistry, and molecular biology
I J Goldberg1,M Merkel1
Division of Preventive Medicine and Nutrition, Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, NY 10032, USA.
DOI: 10.2741/goldberg Volume 6 Issue 3, pp.388-405
Published: 01 March 2001
(This article belongs to the Special Issue Lipid and lipoprotein metabolism)

Lipoprotein lipase (LpL) is the primary enzyme responsible for conversion of lipoprotein triglyceride into free fatty acids and monoglyderides. This permits their uptake into muscle and adipose. The roles of this enzyme in normal and altered physiology are reviewed. In addition, the relationship of LpL activity and genetic variations of LpL and human disease are summarized.

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I J Goldberg, M Merkel. Lipoprotein lipase: physiology, biochemistry, and molecular biology. Frontiers in Bioscience-Landmark. 2001. 6(3); 388-405.