Open Access
Article
T cell signaling of macrophage function in inflammatory disease
R D Stout1,J Suttles1
1
Department of Microbiology, James H. Quillen College of Medicine, Box 70579, East Tennessee State, University Johnson City, TN 37614-0579, USA. stout@access.etsu-tn.edu
DOI: 10.2741/A183 Volume 2 Issue 4, pp.197-206
Published: 01 May 1997
Abstract

Macrophages play diverse roles in episodic T cell-mediated inflammatory diseases such as multiple sclerosis and rheumatoid arthritis, function as accessory cells for T cell activation, as pro-inflammatory cells, as effector cells which mediate tissue damage, and as anti-inflammatory cells which promote wound healing. In addition to the many roles of T cell-derived cytokines in differentially modulating these diverse macrophage activities, research over the last few years has demonstrated that contact-dependent signaling which occurs during T cell-macrophage adhesion is a critical triggering event in the activation of macrophage function. Substantial research emphasis has been placed on CD40 as a mediator of contact dependent signaling. However, other membrane-anchored receptor:ligand pairs may also contribute to the stimulation of macrophage function. This is a brief review of the rapidly expanding, but still incomplete, knowledge of how T cells, through both contact-dependent and cytokine signals, regulate macrophage function during inflammatory disease.

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R D Stout, J Suttles. T cell signaling of macrophage function in inflammatory disease. Frontiers in Bioscience-Landmark. 1997. 2(4); 197-206.