Open Access
Article
Transcription-driven DNA supercoiling and gene expression control
Chien-Chung Chen1,Hai-Young Wu1
1
Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
DOI: 10.2741/968 Volume 8 Issue 4, pp.430-439
Published: 01 January 2003
(This article belongs to the Special Issue DNA supercoiling and gene expression)
Abstract

DNA supercoiling plays important roles in gene expression regulation, although, the underlying mechanisms whereby DNA supercoiling modulates gene expression remain elusive. The fact that the transcription process itself generates DNA supercoiling has further complicated the issue. Transcription-driven DNA supercoiling is local and transient. Such a DNA supercoiling effect is likely to play important roles in controlling complex gene expression regulation. Using the suppression of the leu-500 mutation in Salmonella typhimurium topA mutants as a model system, we put forward our view of the effects of transcription-driven DNA supercoiling on gene expression control.

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Chien-Chung Chen, Hai-Young Wu. Transcription-driven DNA supercoiling and gene expression control. Frontiers in Bioscience-Landmark. 2003. 8(4); 430-439.