Open Access
Article
Fatty acid ethyl esters: toxic non-oxidative metabolites of ethanol and markers of ethanol intake
Catherine A Best1,Michael Laposata1
1
Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
DOI: 10.2741/931 Volume 8 Issue 5, pp.202-217
Published: 01 January 2003
(This article belongs to the Special Issue Lipid binding, modifying and transferring proteins)
Abstract

This report describes the biochemistry of fatty acid ethyl esters (FAEE), non-oxidative metabolites of ethanol, and their clinical significance. We review information regarding the enzymes responsible for FAEE synthesis and degradation, and the mechanisms involved with the intracellular and extracellular transport of FAEE and FAEE-mediated cytotoxicity. Also a summary of reports on the emerging clinical significance and diagnostic utility of FAEE as short and long-term markers of alcohol consumption, and the methodological aspects of FAEE assessment is included.

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Catherine A Best, Michael Laposata. Fatty acid ethyl esters: toxic non-oxidative metabolites of ethanol and markers of ethanol intake. Frontiers in Bioscience-Landmark. 2003. 8(5); 202-217.