Open Access
Creating polyketide diversity through genetic engineering
James T Kealey1
Kosan Biosciences, 3832 Bay Center Place, Hayward, CA 94545, USA.
DOI: 10.2741/885 Volume 8 Issue 3, pp.1-13
Published: 01 January 2003
(This article belongs to the Special Issue Current topics in lead discovery)

Modular polyketide synthases (PKS) are large multifunctional enzymes that synthesize complex polyketides, a therapeutically important class of natural products. The linear order and composition of catalytic sites that comprise the PKS represent a "code" that determines the identity of the polyketide product. By re-programming the PKS through genetic engineering, it is possible to alter the code in a predictable manner to create specific structural modifications of polyketides and to produce new libraries of these natural products.

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James T Kealey. Creating polyketide diversity through genetic engineering. Frontiers in Bioscience-Landmark. 2003. 8(3); 1-13.