Open Access
Identification of biomarkers for bone union promoted by mechanical stimulation
Yanjie Guo1,Shangchun Guo1,Nanji Lu1,Yimin Chai1,Xingang Yu1,*
Department of Orthopedic Surgery, Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, China
DOI: 10.2741/4356 Volume 20 Issue 7, pp.1036-1046
Published: 01 June 2015
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
*Corresponding Author(s):  
Xingang Yu

At present, the identity of the proteins that participate in mechanical stimulation during the fracture healing process is not known. Here, we screened for and identified 299 proteins that are expressed in various stages of mechanically stimulated fracture healing. Among these biomarkers, 54 proteins were differentially expressed during all three recovery time points. Gene ontology (GO) analysis and selected biomarker candidates were used to determine their involvement in biological processes required for mechanically stimulated healing. The levels of cofilin-1 and A2HSG protein were significantly upregulated in the forth week after fracture suggesting that that they play a role in mechanically stimulated fracture healing.

Key words
iTRAQ,Mechanical Stimulation,Fracture Healing
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Yanjie Guo, Shangchun Guo, Nanji Lu, Yimin Chai, Xingang Yu. Identification of biomarkers for bone union promoted by mechanical stimulation. Frontiers in Bioscience-Landmark. 2015. 20(7); 1036-1046.