Open Access
The role of 14-3-3 proteins in gynecological tumors
Wenwen Zhang1,Qi Shen1,Miaomiao Chen1,Ying Wang1,Qingfeng Zhou1,Xuejiao Tao1,Xueqiong Zhu1,*
Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China
DOI: 10.2741/4348 Volume 20 Issue 6, pp.934-945
Published: 01 June 2015
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
*Corresponding Author(s):  
Xueqiong Zhu

A large family of highly conserved cellular 14-3-3 proteins plays key roles in the regulation of central physiological pathways such as metabolism, protein trafficking, signal transduction, apoptosis and regulation of cell cycle. The involvement of these proteins in the regulation of various tumor suppressor genes and oncogenes points to their potential role in human cancer. According to some, the 14-3-3 proteins in gynecological tumors, promote gynecological tumors whereas others suggest that 14-3-3 proteins function as tumor suppressors in such tumors. Here, we review the use of 14-3-3 proteins as novel markers for screening and early diagnosis of gyncyological malignancies, and in monitoring the effectiveness of treatment. 14-3-3 proteins are proposed to be used as prognostic factors and as specific target in the treatment of cancers.

Key words
HPV,14-3-3 protein,Gynecological Tumors,Review
Share and Cite
Wenwen Zhang, Qi Shen, Miaomiao Chen, Ying Wang, Qingfeng Zhou, Xuejiao Tao, Xueqiong Zhu. The role of 14-3-3 proteins in gynecological tumors. Frontiers in Bioscience-Landmark. 2015. 20(6); 934-945.