Open Access
Review
Systemic inflammation and multiple organ injury in traumatic hemorrhagic shock
Huaizheng Liu1,Xuefei Xiao1,Chuanzheng Sun1,Dao Sun1,Yayong Li1,Mingshi Yang1,*
1
Emergency and Intensive Care Center, the third Xiangya Hospital of Central South University, Changsha, Hunan, China
DOI: 10.2741/4347 Volume 20 Issue 6, pp.927-933
Published: 01 June 2015
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
*Corresponding Author(s):  
Mingshi Yang
E-mail:  
lhz3385@yeah.net
Abstract

Traumatic hemorrhagic shock (HS) is a severe outcome of traumatic injury that accounts for numerous traumatic deaths. In the process of traumatic HS, both hemorrhage and trauma can trigger a complex cascade of posttraumatic events that are related to inflammatory and immune responses, which may lead to multiple organ injury or even death. From a mechanistic perspective, systemic inflammation and organ injury are involved coagulation, the complement system, impaired microcirculation and inflammatory signaling pathways. In this review, we discuss the systemic inflammation and multiple organ injury in post-traumatic HS.

Key words
Systemic Inflammation,Multiple Organ Injury,Hemorrhagic Shock,Review
Share and Cite
Huaizheng Liu, Xuefei Xiao, Chuanzheng Sun, Dao Sun, Yayong Li, Mingshi Yang. Systemic inflammation and multiple organ injury in traumatic hemorrhagic shock. Frontiers in Bioscience-Landmark. 2015. 20(6); 927-933.