Open Access
Review
KIT gene mutations in gastrointestinal stromal tumor
Weiming Kang1,Changzhen Zhu1,JianChun Yu1,*,Xin Ye1,ZhiQiang Ma1
1
Department of General Surgery, Peking Union Medical College Hospital, CAMS and PUMC, Beijing, China
DOI: 10.2741/4346 Volume 20 Issue 6, pp.919-926
Published: 01 June 2015
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
*Corresponding Author(s):  
JianChun Yu
E-mail:  
yu_jch@yeah.net
Abstract

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. It arises in the stomach, small intestine, colon, rectum and esophagus. KIT gene mutation is a feature of GIST, in addition to PDGFRA gene mutation. KIT gene mutations have been observed to be involved in the development of GIST, its recurrence after surgery and chemotherapy resistance in GIST. Exons 13, 17, 9, and mainly exon 11 are concerned in these biological behaviors of GIST. In this review, we will discuss on the involvement of KIT gene mutations in the tumorigenesis, recurrence and chemotherapeutic resistance of GIST.

Key words
KIT,Gene Mutation,Gastrointestinal Stromal Tumor,Review
Share and Cite
Weiming Kang, Changzhen Zhu, JianChun Yu, Xin Ye, ZhiQiang Ma. KIT gene mutations in gastrointestinal stromal tumor. Frontiers in Bioscience-Landmark. 2015. 20(6); 919-926.