Open Access
HGF and c-Met in pathogenesis of endometrial carcinoma
Min Li1,Xiaoyan Xin1,Tingting Wu1,Teng Hua1,Hongbo Wang1,*
Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China
DOI: 10.2741/4328 Volume 20 Issue 4, pp.635-643
Published: 01 January 2015
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
*Corresponding Author(s):  
Hongbo Wang

Hepatocyte growth factor (HGF) regulates cell growth, motility, and morphogenesis of various types of cells via its receptor c-Met. In the growth of endometrium, HGF/c-Met signaling promotes the proliferation of both endometrial epithelial cells and stromal cells. In the onset and development of several cancers, HGF/c-Met signaling drives carcinogenesis and cancer invasion and metastasis. In endometrial carcinoma (EC), accounting for a majority of cancer-related morbidity and mortality among women, the increased expression of HGF and c-Met signaling is associated with a poor prognosis of EC patients. Thus, we will discuss the role of HGF and c-Met in the EC pathogenesis in this review.

Key words
HGF,endometrial carcinoma,TNF-alpha,TIMP-2,Review
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Min Li, Xiaoyan Xin, Tingting Wu, Teng Hua, Hongbo Wang. HGF and c-Met in pathogenesis of endometrial carcinoma. Frontiers in Bioscience-Landmark. 2015. 20(4); 635-643.