Open Access
Review
Respiratory supercomplexes: plasticity and implications
Christina A. Porras1,Yidong Bai1,*
1
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
DOI: 10.2741/4327 Volume 20 Issue 4, pp.621-634
Published: 01 January 2015
(This article belongs to the Special Issue Mitochondrial bioenergetics in human health)
*Corresponding Author(s):  
Yidong Bai
E-mail:  
baiy@uthscsa.edu
Abstract

The plasticity model of the electron transport chain has slowly begun to replace both the liquid model of free complexes and the solid model of supercomplexes. The plasticity model predicts that respiratory complexes exist and function both as single complexes and as supercomplexes. The advantages of this system is an electron transport train which is able to adapt to changes in its environment. This review will investigate the current body of work on supercomplexes including their assembly, regulation, and plasticity, and particularly their role in the generation of reactive oxygen species and aging.

Key words
Supercomplex,Mitochondria,Respiration,ROS,Review
Share and Cite
Christina A. Porras, Yidong Bai. Respiratory supercomplexes: plasticity and implications. Frontiers in Bioscience-Landmark. 2015. 20(4); 621-634.