Open Access
Review
Morphological control of mitochondrial bioenergetics
Tianzheng Yu1,Li Wang1,Yisang Yoon1,*
1
Department of Physiology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA
DOI: 10.2741/4306 Volume 20 Issue 2, pp.229-246
Published: 01 January 2015
(This article belongs to the Special Issue Mitochondrial bioenergetics in human health)
*Corresponding Author(s):  
Yisang Yoon
E-mail:  
yyoon@gru.edu
Abstract

The major function of mitochondria is production and supply of cellular energy. Mitochondria are highly dynamic organelles undergoing frequent shape changes via fission and fusion. Many studies have elucidated the molecular components mediating fission and fusion and their regulatory mechanisms, and mitochondrial shape change is now recognized as an essential cellular process that is closely associated with functional states of mitochondria. This review updates the recent advancements in fission and fusion mechanisms, and discusses the bi-directional relationship between mitochondrial morphology and energetic states in physio-pathological settings.

Key words
Mitochondria,Fission,Fusion,Morphology,Dynamics,DLP1,Drp1,Mfn,OPA1,Bioenergetics,Review
Share and Cite
Tianzheng Yu, Li Wang, Yisang Yoon. Morphological control of mitochondrial bioenergetics. Frontiers in Bioscience-Landmark. 2015. 20(2); 229-246.