Open Access
Review
MicroRNAs in human glioblastoma: from bench to beside
Hongxiang Wang1,Tao Xu1,Ying Jiang1,Yong Yan1,Rong Qin1,Juxiang Chen1,*
1
Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
DOI: 10.2741/4300 Volume 20 Issue 1, pp.105-118
Published: 01 January 2015
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
*Corresponding Author(s):  
Juxiang Chen
E-mail:  
juxiangchen_cz@163.com
Abstract

Glioblastoma (GBM) is the most common and malignant adult primary brain tumor and one of the most lethal types of all cancers. Currently, despite interventional therapy (e.g. multimodal treatments with surgery, radiotherapy and chemotherapy), the overall prognosis for GBM patients remains poor. Thus, it is necessary to understand the molecular pathogenesis of GBM, which provides new insight into modern therapy. As a novel molecule, microRNA (miRNA) contributes to the pathogenesis of various types of tumor, including GBM. So far, miRNA has been shown to function in regulating protein-coding gene expression. This allows miRNAs to have direct function in regulation of various cellular events, including cell proliferation, apoptosis, and differentiation. Great progress has been made in identifying novel tumor-related miRNAs and their potential target genes. In this review, we focus on the most current research in miRNAs and their role in GBM regulation. In addition, we summarize some miRNAs found as biomarkers in GBM and their role in treatment.

Key words
miRNA,Glioblastoma,Biogenesis,Signaling Pathway,Therapy,Review
Share and Cite
Hongxiang Wang, Tao Xu, Ying Jiang, Yong Yan, Rong Qin, Juxiang Chen. MicroRNAs in human glioblastoma: from bench to beside. Frontiers in Bioscience-Landmark. 2015. 20(1); 105-118.