Open Access
Review

The role of microRNAs in skeletal muscle health and disease

Tyler J. Kirby1,2,Thomas Chaillou1,2,John J. McCarthy1,2,*
1
Center for Muscle Biology, University of Kentucky, Lexington, KY, USA
2
Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA
DOI: 10.2741/4298 Volume 20 Issue 1, pp.37-77
Published: 01 January 2015
(This article belongs to the Special Issue Mechanisms of skeletal muscle dysfunction and preventative measures)
*Corresponding Author(s):  
John J. McCarthy
E-mail:  
jjmcca2@email.uky.edu
Abstract

Over the last decade non-coding RNAs have emerged as importance regulators of gene expression. In particular, microRNAs are a class of small RNAs of ~ 22 nucleotides that repress gene expression through a post-transcriptional mechanism. MicroRNAs have been shown to be involved in a broader range of biological processes, both physiological and pathological, including myogenesis, adaptation to exercise and various myopathies. The purpose of this review is to provide a comprehensive summary of what is currently known about the role of microRNAs in skeletal muscle health and disease.

Key words

MyomiR, Exercise, Hypertrophy, Atrophy, Muscular dystrophy, Review

Share and Cite
Tyler J. Kirby, Thomas Chaillou, John J. McCarthy. The role of microRNAs in skeletal muscle health and disease. Frontiers in Bioscience-Landmark. 2015. 20(1); 37-77.