Open Access
Review

ADAMTS-18: A metalloproteinase with multiple functions

Jianlu Wei1,3,Chuan-ju Liu1,4,Zongdong Li2,*
1
Department of Orthopaedic Surgery, New York University Medical Center, New York, NY, 10003, USA
2
Department of Medicine, SUNY Stony Brook University, Stony Brook, NY 11794, USA
3
Department of Orthopaedic Surgery, Shandong University School of Medicine, Jinan, Shandong 250012, PR China
4
Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
DOI: 10.2741/4296 Volume 19 Issue 8, pp.1456-1467
Published: 01 June 2014
*Corresponding Author(s):  
Zongdong Li
E-mail:  
zongdongli@yahoo.com
Abstract

ADAMTS-18 is a member of a disintegrin and

metalloproteinase with thrombospondin motifs (ADAMTS)

family of proteases, which are known to play important

roles in development, angiogenesis and coagulation;

dysregulation and mutation of these enzymes have been

implicated

in

many

disease

processes,

such

as

inflammation,

cancer,

arthritis

and

atherosclerosis.

Mutations of ADAMTS-18 have been linked to abnormal

early eye development and reduced bone mineral density.

In this review, we briefly summarize the structural

organization and the expression of ADAMTS-18. We will

also focus on the emerging role of ADAMTS-18 in several

pathophysiological

conditions

which

include:

hematological diseases, tumorgenesis, osteogenesis, eye-

related diseases, central nervous system disorders, and last

but not least a research perspective of ADAMTS-18 and its

potential as a promising diagnostic and therapeutic target.

Key words

ADAMTS-18, Alternative forms, Hemostasis,

Tumor suppresser gene, Bone, Eye, Central nervous

system, Review

Share and Cite
Jianlu Wei, Chuan-ju Liu, Zongdong Li. ADAMTS-18: A metalloproteinase with multiple functions. Frontiers in Bioscience-Landmark. 2014. 19(8); 1456-1467.