Open Access
The role of molecular biology in the diagnosis of lymphoid neoplasms
Marco Pizzi1,Anna Gazzola1,Claudia Mannu1,Stefano A Pileri1,Elena Sabattini1,Stefano A Pileri1
Department of Medicine, DIMED, General Pathology,Cytopathology Unit, University of Padova, Padova, Italy
DOI: 10.2741/4269 Volume 19 Issue 7, pp.1088-1104
Published: 01 June 2014
(This article belongs to the Special Issue The post-genomic revolution in diagnostic pathology)

In recent years, DNA-arrays, gene expression profiling and next-generation sequencing have elucidated the high complexity of genomic alterations occurring in lymphoid malignancies. These studies have also contributed to the identification of new diagnostic and prognostic biomarkers, which may represent possible targets for new therapeutic approaches. Such recent advances have significantly expanded the application of molecular tests to routine diagnostic hematopathology. It is thus conceivable that next-generation assays will soon flank traditional clonality tests and chromosomal translocation assays in the diagnostic work-up of difficult cases. This review is focused on the application of molecular biology techniques in the study of lymphoid tumors. Both conventional and next-generation tests will be addressed, with particular attention to their application to clinical practice.

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Marco Pizzi, Anna Gazzola, Claudia Mannu, Stefano A Pileri, Elena Sabattini, Stefano A Pileri. The role of molecular biology in the diagnosis of lymphoid neoplasms. Frontiers in Bioscience-Landmark. 2014. 19(7); 1088-1104.