Open Access
Review
The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers
Arindam Paul1,*,Soumen Paul1
1
Department of Pathology and Laboratory Medicine and The University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS, United States of America
DOI: 10.2741/4230 Volume 19 Issue 4, pp.605-618
Published: 01 January 2014
(This article belongs to the Special Issue BRCA1 and BRCA2 role in cancer)
*Corresponding Author(s):  
Arindam Paul
E-mail:  
apaul2@kumc.edu
Abstract

The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2, are the dynamic regulators of genomic integrity. Inherited mutations in these genes are associated with the development of cancer in multiple organs including the breast and ovary. Mutations of BRCA1/2 genes greatly increase lifetime risk to develop breast and ovarian cancer and these mutations are frequently observed in hereditary breast and ovarian cancers. In addition, misregulation and altered expressions of BRCA1/2 proteins potentiate sporadic forms of breast cancer. In particular, both genes contribute to DNA repair and transcriptional regulation in response to DNA damage. Thus, deficiencies of BRCA1/2 functions lead to the accumulation of genetic alterations and ultimately influence the development of cancer. Studies since identification of both BRCA1 and BRCA2 have provided strong evidences for their tumor suppressor activities specifically for breast and ovarian cancer and this article aims to review the current state of knowledge regarding the BRCAs and associated cancer risk.

Key words

BRCA1, BRCA2, Breast Cancer, Ovarian Cancer, Review

Share and Cite
Arindam Paul, Soumen Paul. The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers. Frontiers in Bioscience-Landmark. 2014. 19(4); 605-618.