Open Access
Review
Membranes to achieve immunoprotection of transplanted islets
Julien Schweicher1,Crystal Nyitray1,Tejal A. Desai1,*
1
Therapeutic Micro and Nanotechnology Laboratory, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF), 1700 4th Street, Box 2520, San Francisco, CA, 94158, USA
DOI: 10.2741/4195 Volume 19 Issue 1, pp.49-76
Published: 01 January 2014
*Corresponding Author(s):  
Tejal A. Desai
E-mail:  
tejal.desai@ucsf.edu
Abstract

Transplantation of islet or beta cells is seen as the cure for type 1 diabetes since it allows physiological regulation of blood glucose levels without requiring any compliance from the patients. In order to circumvent the use of immunosuppressive drugs (and their side effects), semipermeable membranes have been developed to encapsulate and immunoprotect transplanted cells. This review presents the historical developments of immunoisolation and provides an update on the current research in this field. A particular emphasis is laid on the fabrication, characterization and performance of membranes developed for immunoisolation applications.

Key words

Cell Immunoisolation, Cell Transplantation, Inorganic Membranes, Macrocapsules, Microcapsules, Organic Membranes, Type 1 Diabetes, Review

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Julien Schweicher, Crystal Nyitray, Tejal A. Desai. Membranes to achieve immunoprotection of transplanted islets. Frontiers in Bioscience-Landmark. 2014. 19(1); 49-76.