Open Access
Review

The role of BRCA1 and BRCA2 in prostate cancer

Dan Li1,3,Easwari Kumaraswamy1,3,Lisa M. Harlan-Williams2,3,Roy A. Jensen1,2,3,*
1
Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
2
Department of Anatomy & Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
3
The University of Kansas Cancer Center, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
DOI: 10.2741/4191 Volume 18 Issue 4, pp.1445-1459
Published: 01 June 2013
(This article belongs to the Special Issue BRCA1 and BRCA2 role in cancer)
*Corresponding Author(s):  
Roy A. Jensen
E-mail:  
rjensen@kumc.edu
Abstract

The familial aggregation of prostate cancer and breast cancer has been observed for almost half a century and about 85% of the inherited breast cancer can be linked to germ-line mutations of BRCA1 (breast cancer 1, early onset) and BRCA2. In this review, we are mainly focusing on the contribution of BRCA1/2 sequence variations to prostate cancer risk and disease progression. We will discuss the biological functions of BRCA1/2 and BRCA1/2-related signaling pathways in prostate cancer biology. The majority of studies supporting the link between BRCA1/2 mutations and prostate cancer are from populations with a high frequency of mutations, such as Ashkenazi Jewish, Icelandic, and U.K. population. BRCA1 can directly interact with the androgen receptor (AR) and Janus kinase (JAK), and can differentially regulate insulinlike growth factor 1 receptor (IGF-IR) expression in an AR-dependent manner. BRCA2 homeostasis in prostate cancer cells has been found to be critical in determining cell fates during prostate cancer progression. This review may be helpful for medical professionals and prostate cancer patients when discussing prostate cancer risks, treatment and prognosis.

Key words

BRCA1, BRCA2, Prostate cancer, Sequence variants, Signaling pathways, Tumor suppressor, Review

Share and Cite
Dan Li, Easwari Kumaraswamy, Lisa M. Harlan-Williams, Roy A. Jensen. The role of BRCA1 and BRCA2 in prostate cancer. Frontiers in Bioscience-Landmark. 2013. 18(4); 1445-1459.