Open Access

Angiogenesis in liver metastasis of colo-rectal carcinoma

Bo Xu1,Fei Shen1,Jie Cao1,Lin Jia1,*
Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical College, Guangzhou, China
DOI: 10.2741/4190 Volume 18 Issue 4, pp.1435-1443
Published: 01 June 2013
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
*Corresponding Author(s):  
Lin Jia

In liver metastasis of color-rectal carcinoma, angiogenesis is supported by vascular endothelial growth factor (VEGF) and E-selectin while it is suppressed by Netrin-4 and LK-68. Sinusoidal endothelial cells and the hepatocyte-derived extracellular matrix support growth of microvessels in liver metastases of color-rectal cancers. Based on these insights, the new treatment for liver metastasis of color-rectal cancers target diverse pathways and molecules of angiogenesis, especially the VEGF pathway. Additional agents target the cyclooxygenase-2 pathway or follow regimens for inhibiting angiogenesis. In this review, we discuss angiogenesis and treatments avaiable for color-rectal liver metastasis.

Key words

Angiogenesis; Colorectal Cancer; Liver Metastasis, Review

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Bo Xu, Fei Shen, Jie Cao, Lin Jia. Angiogenesis in liver metastasis of colo-rectal carcinoma. Frontiers in Bioscience-Landmark. 2013. 18(4); 1435-1443.